Study Of The Relationship Between Glasgow Prognostic Score And Short-term Prognosis Of Postoperative Colorectal Cancer By Correlation Analysis

Objective:To evaluate the relationship between Glasgow prognostic score(GPS)and short-term prognosis of postoperative colorectal cancer.Methods:In this study,the clinical data of 225 patients with colorectal cancer undergoing colorectal surgery at the First Affiliated Hospital of Guangxi Medical University and pathologically diagnosed as colorectal cancer from January 2015 to December 2015 were retrospectively analyzed.The correlation between different tumor sites,nerve infiltration,vascular invasion,different T stagings,N stagings,M stagings,TNM stagings and preoperative Glasgow prognostic score(GPS)and the correlation between GPS and postoperative prognosis of CRC were discussed,clinical data using SPSS21.0 software for statistical analysis.Results:1.Univariate analysis of postoperative colorectal cancer recurrence or death risk indicated that preoperative CEA,CA724,FIB,GPS and N stagings,M stagings,perineural invasion,vascular or lymphatic invasion,lymph node metastasis,TNM classification,postoperative chemotherapy survival was statistically significant difference(P<0.05).2.The difference of GPS was relevant to the preoperative levels of CA724,FIB,NLR,tumor location and tumor differentiation was statistically significant(P<0.05).3.A Multi-Logistic Regression Analysis of death after the operation of colorectal cancer or recurrent risk demonstrated that CEA(OR:3.416,95%CI:1.186~9.838),vascular or lymphatic invasion(OR:5.631,95%CI:1.328~23.869),postoperative chemotherapy(OR:4.809,95%CI:1.341~17.25),GPS(OR:4.932,95%CI:1.321~21.45)were the independently prognostic fact-ors of colorectal cancer.4.Log-rank test showed that the preoperative levels of CEA,TNM classification,N stagings,M stagings,lymphnode metastasis,neural invasion,vascular or lymphatic invasion,GPS were associated with the increased risk of postoperative death(P < 0.05).5.Cox proportional hazards model suggested that CEA,CA125,vascular or lymphatic invasion and GPS were independent risk factors for survival in patients with colorectal cancer(P <0.05).6.Univariate analysis of postoperative survival prognosis of patients with colorectal cancer with normal CEA levels showed that there was a s-ignificant correlation between preoperative GPS scores,M staging,and prognosis in patients with normal CEA colorectal cancer(P<0.05).7.The Cox proportional hazards regression model showed that M-stage,and preoperative GPS scores were indepen-dent risk factors for the prognosis of colorectal cancer(P<0.05).Conclusions:The GPS was associated with the prognosis of colorectal cancer,and it could be used as a reference index for the prognosis of colorectal cancer.