Correlation Analysis Of Retinal Ganglion Cell-inner Plexiform Layer Thickness In Diabetic Patients

Objective To explore the relationship between the thickness of retinal ganglion cell-inner plexiform layer in diabetic patients with non-diabetic retinopathy and non-proliferative diabetic retinopathy and the relationship between retinal ganglion cell plexiform thickness and TCM classification in diabetic patients,To provide basis for the application of Chinese medicine in the protection of diabetic ganglion cells.MethodsThe study selected March 2017 to January 2018 to go to the Ophthalmology Outpatient Clinic of Guangdong Province No.2 Hospital of Traditional Chinese Medicine,hospital consultation,and 60 patients who were selected according to the inclusion criteria using a random number table.All patients included in the study were treated with Cirrus HD.-Macular scans were performed on the OCT5000 to obtain GCIPL thickness data.At the same time,according to the symptoms of the subjects to be included in the TCM syndrome differentiation,the data obtained by SPSS22.0 statistical software for statistical analysis.Results1.Macular morphological changes in patients with DR such as macular thinning,macular bleed,macular edema,macular epithelium and other abnormalities caused by GCIPL thickness.2.Below the NDR group,the mean thickness of the GCIPL thinning is dominated by the following groups.The mean thickness of the GCIPL in the NPDR group is mainly below the iliac crest,above,below the nose,and below the mean thickness,and the mean thickness of the thickness below and below the iliac crest is statistically There are significant differences.3.The relationship between the course of diabetes and the international classification of diabetic retinopathy by SPEARMAN rank correlation analysis,there is no correlation(r=0.187,P=0.060> 0.05).4.The correlation between average GCIPL thickness and visual acuity in NDR patients was correlated by SPEARMAN rank correlation analysis(r=0.585,P=0.000<0.05).The correlation between average GCIPL thickness and visual acuity in NPDR patients was analyzed by SPEARMAN rank correlation analysis.There was no correlation(r=0.218,P=0.129>0.05).5.Differences in HbA1 c between NDR and NPDR patients were lower than those in NDR patients.6.The average GCIPL thickness and glycosylated hemoglobin levels in the NPDR and NDR groups were not correlated.7.The relationship between the average GCIPL thickness and course of disease in 60 patients with diabetes was analyzed by SPEARMAN rank correlation analysis,and there was no correlation(r=-0.036,P=0.723> 0.05).8.The retinal ganglion cell-inner plexiform thickness in 60 patients with diabetes in this study was correlated with TCM syndrome type(r=-0.233,P=0.019<0.05).The average patient’s average GCIPL thickness was thinner than the patients with deficiency syndrome..Conclusion1.Macular morphological changes in patients with DR can cause GCIPL thickness abnormalities.2.Below the NDR group,the mean thickness of the GCIPL thinning is dominated by the following groups.The mean thickness of the GCIPL in the NPDR group is mainly below the iliac crest,above,below the nose,and below the mean thickness,and the mean thickness of the thickness below and below the iliac crest is statistically There are significant differences.3.The visual acuity of patients in the NDR group correlates with the average GCIPL thickness.4.Blood glucose control was worse in the NPDR group than in the NDR group.5.The average GCIPL thickness in the 60 patients with diabetes in this study was less than that in patients with diabetes.