Traditional Chinese Medicine Knowledge And Case Analysis Of Sipple Syndrome

BackgroundThe Sipple syndrome（multiple endocrine neoplasia typeⅡ,MEN-2A）,a tumor syndrome that involves multiple endocrine organs at the same time or in succession,is a rare familial disease^[1].Its occurrence is related to the mutation of RET gene located on autosomal.RET gene is generally mainly expressed in thyroid C cells,chromaffin cells and parathyroid cells,so Sipple syndrome is mainly characterized by MTC with/without PHEO,PHPT（（1）MTC（2）MTC+PHEO（3）MTC+PHPT（4）MTC+PHEO+PHPT）^[2].What is more,due to the abnormal secretion of hormones,intestine,mucous membrane,cornea,bone and other non-endocrine organs appear lesions.Since the 19th century,,the University of Freiburg in Germany first described Sipple syndrome,since then,there have been many scholars devote themselves to the observation and research of this syndrome:Sipple proposed the basic concept of this syndrome in 1961,and till 1968 Steiner proposed the comprehensiveconcept of the syndrome.To date,although the etiology of Sipple syndrome has not been fully elucidated,through the unremitting efforts of domestic and foreign scholars,500 to more than 1000families have been diagnosed and treated globally,the relationship between RET gene mutation and its inseparable relationship is found,and a more perfect diagnosis system has been established,and modern medical treatment of Western medicine is currently being treated.The main purpose is to remove[3-5]from the endocrine organ tumor.But this is only the research frontiers that modern medicine can touch.The excavation and diagnosis of the cause of disease still need to be studied unremittingly^[3,4,6].But this is only the research frontiers that modern medicine can touch.The excavation and diagnosis of the cause of disease still need to be studied unremittingly.ObjectiveAlthough there is no corresponding name for Sipple syndrome in TCM.Sipple syndrome is mainly composed of MTC,PHPT and PHEO,with clinical manifestations of headache,sweating,palpitation.These clinical manifestations have long been recorded and discussed in TCM.TCM scholars discuss the etiology and pathogenesis,diagnosis and treatment of Sipple syndrome according to the description of the classical medical books with their own clinical experience.Through clinical research,it is fully verified that syndrome differentiation combined with traditional Chinese medicine and Western medicine can effectively treat Sipple synthesis.MethodsThrough a case of Sipple syndrome in Department of Urology and thyroid surgery of the First Affiliated Hospital of Guangzhou University of Chinese Medicine,the research progress of TCM in the etiology,pathogenesis and Chinese medicine treatment of Sipple syndrome is reviewed.Because the clinical manifestation of the typical case involves a variety of TCM syndrome,the study on the changes of TCM syndrome in different periods of this typical case is recorded and analyzed,which provides a certain reference for the diagnosis and treatment of traditional Chinese and Western medicine in the future.ResultsIn this case,the left adrenal tumor was admitted to hospital for physical examination.The clinical symptoms were palpitation and sweating,combined with the family history of adrenal pheochromocytoma and the family history of the thyroid tumor.After the examination,the diagnosis was Sipple syndrome,and left adrenal pheochromocytoma,left thyroid carcinoma and right parathyroid adenoma were given successively.Surgical resection and symptomatic treatment with Chinese medicine,after treatment,patients without palpitation,sweating and other symptoms.Through this case,it is fully demonstrated that in the diagnosis and treatment of rare or complex diseases,we should pay attention to the cooperation between Chinese and Western medicine,and on this basis,we should think about the disease in an all-round way,look for the correlation between different diseases on the same patient,reveal the law of the occurrence and development of the disease,and then pass through the disease.The surface signs of disease look for their inherent problems,and provide directions for further diagnosis and treatment.