Clinical Observation Of Alcoholic Liver Deester Granule Therapy Phlegm-dampness Blocking Alcoholic Fatty Liver

Objective:This topic through the alcohol liver deester granule treatment phlegm wet block type alcoholic fatty liver(AFL)in patients with clinical curative effect observation,to investigate the effects of alcohol liver deester granule on liver/ spleen CT values,ALT,AST,γ-GGT,TC,TG,and TCM syndromes in AFL patients.Method:This study selected the department of hepatobiliary spleen and stomach,affiliated hospital of henan institute of traditional Chinese medicine,October 1,2016 To January 1,2018,all outpatients met the diagnostic criteria,and after inclusion and exclusion criteria screening,sixty patients diagnosed with Phlegm-dampness blocking alcoholic fatty liver were observed,the patients were randomly divided into treatment group and control group,30 cases each.Both groups were given basic treatment(prohibition of alcohol,contraindications of fat and sweet taste,daily appropriate aerobic exercise),the treatment group was given the oral alcohol-liver deester granule on the basis of treatment,there were 12 weeks of treatment in the two groups,and 2,4,8 and 12 weeks after admission were the visiting period,follow-up was conducted 4 weeks after the end of clinical observation.The basic data of the patients were collected,and the TCM symptom scores and syndromes curative effects were observed before and after treatment,imaging and laboratory examination data include liver/spleen CT values,liver function(ALT,AST,γ-GGT),blood lipid(TC,TG)levels.SPSS 21.0 was used for statistical analysis.Result:(1)Prior treatment: the two groups were compared in terms of gender,age,drinking history,medical history and other basic data,liver/spleen CT value,ALT,AST,γ-GGT,TC,TG and TCM clinical symptom score,the differences were not statistically significant(P>0.05)and were comparable;(2)Liver/spleen CT value: at the end of the 12-week course of treatment,the liver/spleen CT values of the treatment group and the control group were significantly higher than those before treatment,and the changes of the treatment group were significantly greater than those of the control group,with statistically significant differences(P<0.05);(3)Imaging efficacy evaluation: treatment group: clinical recovery: 4 cases,significant effect: 4 cases,effective: 17 cases,ineffective: 5 cases,effective rate is 83%;Control group: clinical recovery: 1 case,significant effect: 2 cases,effective: 15 cases,ineffective: 12 cases,effective rate is 60%;The imaging efficacy of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05);(4)TCM clinical symptom score:at the end of the 12-week course of treatment,the scores of TCM clinical symptoms in the treatment group and the control group were significantly lower than before treatment,and the improvement in the treatment group was significantly greater than that in the control group,with statistically significant differences(P<0.05);(5)Therapeutic effect of TCM syndromes: at the end of 12 weeks of treatment,the treatment group was cured: 8 cases,significant effect: 12 cases,effective: 6 cases,ineffective: 4 cases,effective rate was 87%;Control group: cure: 3 cases,significant effect: 5 cases,effective: 13 cases,ineffective: 9 cases,effective rate is 70%;The therapeutic effect of TCM syndromes in the treatment group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05);(6)Liver function: end of 6 weeks treatment,the treatment group and control group liver function(ALT,AST,γ-GGT)levels than before treatment were significantly decreased,moreover,in the treatment group,the changes in liver function(ALT,AST,γ-GGT)were more significant than those in the control group,with statistically significant differences(P<0.05);At the end of the 12-week course of treatment,the levels of liver function(ALT,AST,γ-GGT)in the treatment group and the control group were significantly lower than before treatment,and the differences were statistically significant(P<0.05),but,ALT and γ-GGT levels of patients in the treatment group changed significantly compared with those in the control group,with statistically significant differences(P< 0.05),however,there was no statistically significant difference in AST level between the treatment group and the control group(P>0.05);(7)Blood fat:at the end of the 12-week course of treatment,the serum lipid(TC,TG)level of the treatment group and the control group decreased significantly compared with that before treatment,however,the serum lipid(TC,TG)level of the patients in the treatment group changed significantly compared with that of the control group,and the difference was statistically significant(P<0.05);(8)Safety evaluation: at the end of the 12-week course of treatment,no obvious abnormalities were found in blood routine,urine routine,stool routine,renal function and electrocardiogram of the two groups of patients,during the treatment,no obvious adverse reactions occurred in either group,nor did they withdraw from the study due to adverse reactions.Conclusion: the alcohol liver deester granule can effectively improve the liver fat change under CT in patients with alcoholic fatty liver with phlegm dampness retardation,and reduce the levels of blood ALT,AST,γ-GGT,TC,and TG;To improve TCM syndromes of alcoholic fatty liver with phlegm-dampness block;It has no obvious toxic and side effects and is safe and effective in clinical application.