Changes In Clinical Features Of Inpatients With Prostate Cancer In The Past 17 Years

Objective: To investigate changes of inpatients with prostate cancer in the last 17 years such as age of onset,prostate specific antigen(PSA),Gleason score,prostate cancer staging and positive rate of prostate biopsy.Materials and Methods: A retrospective analysis was conducted in 1231 cases of biopsy patients of urology and 564 patients with prostate cancer who were hospitalized in the First People’s Hospital of Guangzhou from 2000 to 2016.According to the time of diagnose of our hospital and in order to make dates more representative,all the patients were divided into five groups: A group(2000-2005)、B group(2006-2009)、C group(2010-2012)、D group(2013-2014)、E group(2015-2016),The age,PSA、Gleason score、staging and positive rate of prostate biopsy were compared to see whether the indicators of the differences between groups was statistically significant.Results: Five groups means of age、PSA、Gleason score、Transformed Value of TNM staging and prostate biopsy positive rate are respectively 73.36,73.74,72.05,73.40,72.96 years;208.95,190.25,173.19,283.54,148.69 ug/l;6.80,6.73,7.12,6.93,7.32;5.96,6.80,7.05,7.31,6.83 and 48%,43%,37%,44%,39%.There was no significant difference in age、PSA and positive rate of prostate biopsy(P all > 0.05).The Gleason scores of group A and group E,group B and group E were statistically significant(P all<0.05),while the other groups had no significant differences in Gleason score(P all>0.05).There were significant differences in TNM staging score between A group and C group、D group 、E group(P all <0.05),while the other groups had no significant difference in TNM staging score(P all>0.05).Conclusion: Prostate cancer patients in the past 17 years diagnosis of age 、PSA levels and positive rate of prostate biopsy did not change significantly.