| Objectives To investigate the changes of brain function and their association with neurocognitive scales in amnestic mild cognitive impairment(a MCI)using resting-state functional MRI(rs-f MRI)and neurocognitive scales.Methods A total of 106 patients with complaints of memory loss who were enrolled in outpatient service and inpatient service in Department of Neurology of Tangshan Worker’s Hospital from November 2016 to December 2017 and assessed by neurocognitive scales.Ten patients with a MCI were eventually included.Included 11 normal controls matched with age,gender and years of education-matched.They all perform rs-f MRI scans.The resting-state functional MRI(rs-f MRI)data of all participants were acquired and preprocessed by DPARSF.Consistency in the time series of every voxel with its adjacent voxel in the brain was calculate to obtain the Re Ho.Two subjects were excluded by reason of large head movement or poor image quality.In total,19 subjects,including 9 a MCI and 10 normal controls(NC)were included.Using two-sample t test to campare the differences in age,education level and cognitive scores.Using Fisher’s exact test to assess the gender composition between the two groups.The Re Ho plots of the a MCI group and the normal group were compared using SPM12 and REST to calculate the t and P values.The Re Ho value of the a MCI group was correlated with the neurocognitive scales.The r and P values were calculated using SPM12 and REST.Results 9 a MCI patients(71.00±6.344 years;4 males,5 females)and normal controls(66.00±6.600 years;4 males,6 females)were involved.No significant differences were found between a MCI and normal controls for gender,age,years of education(P=0.808,P=0.111,P=1;P>0.05).The ADL score in the a MCI group was 21.67±1.323,and the control group was 21.10±1.287;The MMSE scale in the a MCI group score was 20.78±5.286,and the control group was 27.50±2.593;The Mo CA scale in the a MCI group score was 16.33±4.975,and the control group was 25.40±3.273;The AVLT scores for immediate recall,delayed recall,and recognition were 26.50±3.308,3.11±2.421,and 7.44±4.475 in the a MCI group,and 16.67±3.162,9.90±1.595,and 12.00±2.000 in the control group,respectively.Two groups on ADL score has no significant difference(P>0.05),the other scale examination scores(MMSE,Mo CA, AVLT)had significant difference(P<0.05).Compared with the normal control group,the a MCI group showed lower Re Ho,There were significant differences in the frontal lobe,superior frontal gyrus,middle frontal gyrus,right inferior frontal gyrus,medial frontal gyrus,right precentral gyrus,parietal lobe,superior parietal gyrus,superior parietal lobule,inferior parietal lobule,inferior parietal corner gyrus,posterior central gyrus,prewedge lobe,right corner gyrus,right superior marginal gyrus,cerebral islands,anterior cingulate gyrus and accessory cingulate gyrus,left putamen nucleus,left lentiform nucleus,left palmoid nucleus,left temporal lobe,left transverse temporal gyrus,right marginal lobe(P < 0.01).Correlation analysis showed that the brain region associated with immediate recall was the right temporal lobe.Conclusions 1The overall cognitive function of patients with a MCI was reduced,mainly due to memory loss,and among them,the decrease in immediate recall ability is related to the abnormal activity in the right temporal lobe.2Frontal lobe,parietal lobe,marginal lobe,and basal ganglia region are sensitive brain regions in patients with a MCI.Their damage can lead to cognitive decline. |
PDF Full Text Request