Correlation Research Between CTRP3 And In-stent Restenosis After Coronary Drug-eluting Stent Implantation

Objective:To explore the influencing factors of in-stent restenosis after coronary intervention in patients with coronary heart disease and the relationship between serum CTRP3 level and in-stent restenosis.Methods:From October 2015 to December 2017,patients in the Department of Cardiology at the Dong Guan Branch of the Affiliated Hospital of Yan’an University were enrolled in consecutive 63 patients with in-stent restenosis after drug-eluting stent implantation(ISR group).Randomly selected 70 patients with coronary angiography without in-stent restenosis after drug-eluting stent implantation at the same time as a control group.The clinical features of the two groups(including signs,biochemical indicators,history of underlying diseases,medication dependence,echocardiography findings),coronary angiography data,and interventional treatment were recorded.Multivariate logistic regression was used to analyze the factors related to in-stent restenosis after PCI.Results:1.The prevalence of diabetes in ISR group was significantly higher than that in control group.The levels of LDL-C and lipoprotein-a were higher,and the levels of Hb-A1c(%)and CTRP3 were lower,both the differences were significant;There was no significant difference in the levels of TG,TC,HDL-C,Hb,TB,β2-MG,creatinine,and LVEF;there was no significant difference in the the incidence of smoking,prevalence of hyperlipidemia and hypertension,and dependence on postoperative medication between the two groups.2.Both the number of lesion vessels and stent-grafted vessels were significantly higher in the ISR group than in the control group,but there was no statistically significant difference in the mean number of stents.There was a significant difference in preoperative stenosis,bifurcation lesions,and complex lesions between the two groups;The mean diameter of stents was smaller,the length of total stents was longer,and the number of stents in series was more.The difference was statistically significant;There was No significant difference in the pressure of the balloon,the occlusive lesions and multi-vessel lesions,lesion vessels and stent vessel location between the two groups.3.Correlation analysis showed that serum CTRP3 level was negatively correlated with the number of coronary vessels(r_s=﹣0.805,P<0.001).4.Multivariate logistic regression analysis showed that serum LDL-C levels,serum CTRP3 levels,complex coronary lesions,preoperative lumen stenosis,stent diameter and length were related to in-stent restenosis,and were independent predictive factors of in-stent restenosis.Conclusions:1.Higher levels of serum LDL-C,complex lesions,greater stenosis of the preoperative lumen,smaller stent diameter,longer stent length,and in-stent restenosis have a certain correlation and contribute to in-stent restenosis prediction.2.Decrease of serum CTRP3 level is an independent risk factor for in-stent restenosis,and it has a certain predictive value for the occurrence of in-stent restenosis.