Clinicopathological Features And Prognostic Analysis Of Invasive Ductal Carcinoma With Micropapillary Carcinoma

Objective:To analyze the clinicopathological features of invasive ductal carcinoma with micropapillary carcinoma,compare the clinical characteristics and prognosis between invasive ductal carcinoma with micropapillary carcinoma and invasive ductal carcinoma,and discuss the clinical biological characteristics and prognosis of invasive ductal carcinoma with micropapillary carcinoma.Methods:1 129 cases of invasive ductal carcinoma with micropapillary carcinoma and 258 cases of invasive ductal carcinoma were selected from May 2009 to December 2014 at the Breast Center of the Fourth Hospital of Hebei Medical University and the IDC group were through the random number table method1/2 at the same time.Some clinicopathological features were collected to compare differences,including age,menstrual status,tumor size,clinical stage,lymph node metastasis,presence of vascular tumor thrombus,and female Progesterone receptor(ER/PR)status,human epidermal growth factor receptor-2(HER-2)expression,Ki-67 protein expression,molecular typing,and therapeutic measures.2 The patients were followed up for survival.Statistical analysis was used to analyze the prognosis.Clinical biomarkers related to the prognosis of the two groups were determined.Risk factors related to the prognosis of invasive ductal carcinoma combined with micropapillary carcinoma were explored.3 Apply SPSS 21.0 statistical software to analyze the data.Pearson chi-square test and Fisher’s exact test were used to compare the differences in clinical pathological features between the two groups.Kaplan-Meier method,Log-rank test,and COX proportional regression risk model were used for survival analysis.P value<0.05 The difference was statistically significant.Results:1.Incidence of micropapillary carcinoma and invasive ductal carcinoma with micropapillary tumor incidenceThe incidence of invasive micropapillary carcinoma in this group is approximately 2.5%(192/7527);the incidence of invasive ductal carcinoma with micropapillary carcinoma is approximately 1.9%(144/7527).2.Clinicopathological features between IMPC group and IDC groupThere were significant differences in lymph node metastasis,presence of vascular tumor emboli,and positive ER expression in IMPC group and IDC group(P<0.05),and in age,menstruation status,tumor size,clinical stage,PR expression,HER-2 expression,There was no statistical difference in Ki-67protein expression and molecular typing(P>0.05).In the postoperative adjuvant treatment,more patients in the IMPC group received radiotherapy and endocrine therapy,and the differences were statistically significant(P<0.05).3.Prognostic analysis of IMPC group and IDC groupThe disease free survival(DFS)of IMPC group and IDC group at 3 years and 5 years were 88.4%and 94.2%,82.0%and 87.5%,X~2=4.734,P=0.030,respectively,3 years and 5 years.The overall survival(OS)of the year was(95.3%and 98.4%,90.5%and 95.4%,X~2=5.961,P=0.015),and the difference was statistically significant.Tip:Compared to IDC,IDC&IMPC have a poor prognosis.4.Risk factors affecting the prognosis of invasive ductal carcinoma with micropapillary carcinomaLog-rank test univariate analysis showed that lymph node metastasis status,histological grade,and presence or absence of vascular tumor embolus were risk factors for prognosis of breast invasive ductal carcinoma with micropapillary carcinoma(P<0.05).).Multivariate analysis of the COX proportional regression risk model showed that lymph node metastasis was an independent risk factor for the prognosis of invasive ductal carcinoma with micropapillary carcinoma(P<0.05).Conclusions:1.The incidence of invasive ductal carcinoma with micropapillary carcinoma is approximately 1.9%.2.Compared with invasive ductal carcinoma,invasive ductal carcinoma with micropapillary carcinoma has higher lymph node metastasis rate,stronger lymphovascular invasiveness,and higher ER positive expression rate.3.Compared with invasive ductal carcinoma,both DFS and OS at 3 and5 years showed worse prognosis in invasive ductal carcinoma with micropapillary carcinoma.4.The status of lymph node metastasis is an independent risk factor that influences the poor prognosis of invasive ductal carcinoma with micro-emulsion cancer.