The Clinicopathologic Features Of Non-small Cell Lung Cancer With Elevated Serum NSE

Objective: To investigate the clinicopathologic features of patients with non-small cell lung cancer with elevated serum NSE undergoing radical surgery.Methods: A total of 157 patients with non-small cell lung cancer who had undergone radical surgical treatment from January 2014 to December 2017 and had complete clinical data were collected from Department of Thoracic Surgery,Fujian Medical University Union Hospital.According to the serum preoperative serum NSE,the patients were divided into two groups: the elevated group and the normal group.The clinicopathological characteristics of the two groups of patients with non-small cell lung cancer were compared,such as gender,age,smoking history,pathological type,T stage,lymph node metastasis,and TNM staging,and analyzing the clinicopathological features of adenocarcinoma and squamous cell carcinoma in patients with non-small cell lung cancer with elevated serum NSE,and to analyze the clinicopathological characteristics of the overall NSE level distribution in non-small cell lung cancer,as well as the relationship between clinical pathological characteristics and serum NSE levels in adenocarcinoma and squamous cell carcinoma patients.Result: Among the 157 patients,32 cases were elevated in the serum NSE group,accounting for 20.4%,and 125 cases were in the NSE normal group,accounting for 79.6%.The univariate analysis showed that there was no significant correlation with gender,age,smoking history,pathological type,T stage,lymph node metastasis n NSE and normal NSE groups(P>0.05),there was a significant correlation with TNM staging in NSE and normal NSE groups(P<0.05).There were significant differences in smoking history and TNM staging between the two groups of patients with adenocarcinoma and squamous cell carcinoma in the elevated serum NSE group(P<0.05).The overall distribution of serum NSE levels in non-small cell lung cancer patients was gender-specific.There was a significant difference in the pathological type,TNM staging(p<0.05),and there was no correlation between the clinicopathological features and serum NSE levels in non-small cell lung adenocarcinoma and squamous cell carcinoma.Conclusions: Compared with the normal serum NSE level of Non-small cell lung cancer patients who underwent radical surgical treatment,The early stage composition of TNM stage in NSCLC patients with The Elevated serum NSE was Significantly reduced,but the medium-term proportion increased significantly.There are similar results in the overall distribution of serum NSE levels.The higher the NSE level,the later the stage,the NSE level should be closely related to the malignancy of non-small cell lung cancer,and positively correlated.In addition,smoking,male and squamous cell carcinoma were among the patients with higher NSE level,indicating a corresponding increase in malignancy in patients with smoking,male and squamous cell carcinoma.Therefore,serum NSE should be regarded as a biological indicator of clinical pathologic features of non-small cell lung cancer and should be attached importance in clinical diagnosis and treatment,and its specific mechanism is worth further exploration.