Clinical Evaluation Of "San Cai Of Health Of Brain" Moxibustion For Treatment Of Mild Cognitive Impairment

Objective:The purpose of this study is to observe the clinical efficacy and safety of early intervention on " San Cai of Health of Brain" moxibustion for treatment of mild cognitive impairment.Methods:This study used a completely randomized controlled clinical study,130 patients with MCI that were adapted to the experiental study on the inclusion criteria were randomly assigned to a moxibustion group and a drug group.According to the different treatment,the moxibustion group points the three acupoints such as GV20、CV8 and KI1 in Every other day at a time and a total of eight weeks of treatment.The drug group takes orally nimodipine 30mg/time and 1 time a day for 8 weeks.Using The Mini-Mental Status Examinination(MMSE)and Montreal Cognitive Assessment(MoCA)and Event-related Potentials P300(P300)for curative effect evaluation index,respect before and after 8 month weeks treatment,two treatment schemes evaluation for the treatment of the clinical efficacy and security of MCI.Results:1)Two groups of subjects were grouped equilibrium,and baseline is consistent,and comparability is good.2)After 8 weeks treatment,the group of moxibustion and drug group also can improve the MMSE score and MoCA scores of MCI patients;and also shorten the latent period of P300 of MCI patients.the difference was statistically significant(P<0.01);3)After 8 weeks treatment,moxibustion group in improving MMSE and MoCA scores,shorten the latent period of P300 is better than the drug group,the difference was statistically significant(P<0.05);4)before and after treatment,the MMSE score,MoCA score and P300 latency were negatively correlated in the two groups of patients with MCI.(P<0.05)Conclusions:1.The " San Cai of Health of Brain" moxibustion and medicine nimodipine canimprove the cognitive function of patients with MCI,the " San Cai of Health of Brain" moxibustion on improving cognitive function in patients with MCI is better than that of nimodipine.2.P300 latency is helpful in evaluating the changes of the cognitive function in patients with MCI.3.The "San Cai of Health of Brain" moxibustion is an effective interventions to improve the cognitive function of MCI,and has the characteristics of safety,convenient operation,beneficial to the aging society in large area community promotion.