Resting State Functional Magnetic Resonance Imaging Study In Bipolar Mania Based On ReHo And ALFF

Objective In this study,resting state functional magnetic resonance imaging(ReHo and ALFF)was used to study the characteristics of spontaneous brain activity in patients with bipolar mania at rest.To explore the different brain functional areas in patients with bipolar mania compared with normal people,and to provide research basis for the pathophysiological mechanism of bipolar mania.Methods Bipolar I(current episode manic)diagnostic criteria of 19 patients with bipolar mania accord with the diagnostic and statistical manual of mental disorders,fifth edition,DSM-V in Hangzhou Seventh People’s Hospital.At the same time,20 healthy subjects with matching age,gender and education level were recruited from the society as healthy control group.All subjects were recruited to undergo the 1.5 Tesla resting state functional magnetic resonance imaging scanning by GE 1.5t Signa HDxt magnetic resonance scanner,which produced by the General Electric company.All subjects were graded on the bech-rafaelsen mania scale(BRMS)within a week before the scan.Regional homogeneity(ReHo)analysis method was used to evaluate the degree of synchronization of neuron activity in local brain areas,while the amplitude of low frequency fluctuation(ALFF)analysis method was used to evaluate the intensity of neuron activity in local brain areas.RESTplus V1.21 toolbox was used to preprocess,ReHo and ALFF analyze RS-MRI original data on Matlab platform.Comparison between groups was performed by t test of two independent samples and multiple comparison correction of GRF(voxel size=0.001,cluster size=0.01),so as to obtain corrected difference brain areas.Finally,the corresponding ReHo value and ALFF value in the brain regions of each subject were extracted,and Pearson correlation analysis was respectively performed on them with age,total course of disease,years of education and BRMS score.Results 1.ReHo analysis results: compared with the healthy control group,the bipolar manic group had lower ReHo in the right medial frontal gyrus and right angular gyrus,and no brain regions with elevated ReHo were found.2.ALFF analysis results: compared with the healthy control group,the bipolar manic group had increased ALFF in the left precuneus and bilateral caudate nucleus,and no brain regions with decreased ALFF were found.3.Pearson correlation analysis results: there was a significant negative correlation between the right median frontal gyrus ReHo value and age(p=0.0143,r=-0.5520),while other brain regions showed no significant correlation with age,total course of disease,years of education and BRMS score.Conclusion 1.The analysis by ReHo and ALFF showed that there were multiple brain regions of difference between the bipolar manic group and the healthy control group,which suggested that the activity of neurons in multiple brain regions of the bipolar manic patients was abnormal in the resting state.2.There was no overlap between ReHo and ALFF between the bipolar group and the healthy control group,which suggested that there were different forms of neuronal activity in different brain regions in the bipolar group.3.Abnormal neuronal activity in right medial frontal gyrus,right angular gyrus,left precuneus and bilateral caudate nucleus may be associated with mood regulation disorder,reckless behavior,attention disorder,sleep disorder and aggressive behavior in bipolar manic patients.4.There was a significant negative correlation between ReHo value in the right median frontal gyrus and age,which suggested that the right median frontal gyrus was involved in some functional compensation,and its compensation ability decreased with age.