The Correlation Between Serum Gp73 And IL-6 Levels And Hepatic Fibrosis Index In Chronic HBV Infected Patients

Objective: To investigate the expression of serum GP73 and IL-6 in patients with chronic HBV infection,and to analyze the correlation between GP73 and IL-6 and hepatic fibrosis index.Methods : 66 cases of chronic HBV infection were collected,including 30 cases of chronic hepatitis B and 36 cases of hepatitis B cirrhosis.Thirty-one health examineesin the same period were selected as control group.The contents of GP73 and IL-6 were detected by ELISA and PCIII,IV-C and LN were detected by magnetic particle chemiluminescence.Comparison of serum GP73,IL-6 and hepatic fibrosis in patients with chronic HBV infection,Spearman correlation analysis was used to analyze the correlation between serum GP73,IL-6 and hepatic fibrosis index.Results: Compared with the control group,the serum levels of GP73,IL-6,IV-C and LN increased gradually with the aggravation of chronic HBV infection,and there were significant differences among the groups(P < 0.05).The serum levels of PCIII increased with the aggravation of the disease,but there was no significant difference between CHB group and LC group(P > 0.05).With the increase of Child-Pugh grade in patients with hepatitis B and cirrhosis,there were significant differences in serum IV-C and LN levels between groups(P < 0.05).There was no significant difference in serum IL-6,GP73 and PC III levels between groups(P > 0.05).The results of correlation analysis showed that the serum GP73 levels in CHB group were positively correlated with IL-6,PC III and IV-C(P < 0.05),and Spearman correlation coefficients were 0.4404,0.5953 and 0.4442,respectively,without significant correlation with LN.Serum GP73 level was positively correlated with IL-6 and IV-C in LC group(P < 0.05).Spearman correlation coefficients were 0.4347 and 0.5343,respectively,which were not significantly correlated with PCIII and LN.Serum IL-6 level was positively correlated with PC III、IV-C and LN in CHB group(P<0.05),Spearman correlation coefficients were 0.4195,0.391 and 0.3942.Serum IL-6 levels in LC group were positively correlated with IV-C and LN(P<0.05).Spearman correlation coefficients were 0.5245 and 0.4468,respectively.There was no significant correlation with PCIII.Conclusion: Serum GP73 and IL-6 levels are closely related to the progression of chronic HBV infection.Serum GP73 and IL-6 levels are closely related to hepatic fibrosis indicators,and may become important serological indicators for evaluating the degree of hepatic fibrosis.