| Research purposes:This study aims to observe the symptoms of acute bronchitis,heat and stagnation of lung syndrome by observing mulberry stagnation and cough prescription(including frequency of coughing before and after treatment,color of cough,fever,chest fullness,lung signs,TCM symptom scores and related serum laboratory indicators,to explore the clinical efficacy of adding mulberry stagnation and cough prescription,to provide a practical basis for clinically better treatment of acute bronchitis with integrated Chinese and Western medicine,and ultimately to alleviate the suffering of patients,Shorten the course of the disease.Research method:During the period from February 2018 to February 2019,60 patients who were admitted to the Department of Respiratory Medicine of Nanjing Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Traditional Chinese Medicine,met the diagnostic criteria of acute bronchitis and phlegm-heat syndrome.They were randomly divided into two groups.The group,the treatment group and the control group each had 30 people.The patients in the treatment group were treated with mulberry stagnation and cough prescription on the basis of conventional western medicine treatment.The Chinese pharmacy of Nanjing Traditional Chinese Medicine and Western Medicine Hospital was uniformly prepared as a traditional Chinese medicine decoction to facilitate the patient to take it.Each bottle is 100ml,50ml is 1 dose,each 25ml,once in the morning and evening.The control group received oral amoxicillin dispersible tablets half an hour after meals,500 mg/time,3 times/day;ambroxol hydrochloride tablets,30 mg/time,3 times/day,both groups were treated for 1 week.Subjects were given a VAS subjective score of cough severity before treatment,on the third day after treatment,and on the 7th day after treatment.The changes of TCM symptom scores were observed before treatment and on the 7th day after treatment,and the comprehensive curative effect was judged.The changes of serum C-reactive protein,interleukin-8 and tumor necrosis factor-a in the serum were measured before and after treatment to evaluate the clinical efficacy.The patient’s vital signs and adverse reactions were monitored during the treatment,and seven routine blood tests,seven liver functions,and seven renal functions were tested before and after the treatment as safety indicators.Result:1.On the third day after treatment,the VAS scores and total scores of the two groups were compared.There was no significant difference in the scores of single points except cough(P>0.05).Academic significance(P<0.05).2.On the 7th day after treatment,the VAS scores and total scores of the two groups were compared.The scores of the treatment group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).3.On the 7th day after treatment,the differences between the two groups,except for fever,chest fullness,facial redness,and lung acuity,were not statistically significant(P>0.05).Symptom score,total score of main symptom,total score of secondary disease and total score of all symptoms showed statistical significance(P<0.05).4.According to the comprehensive efficacy judgment standard,the total effective rate of the treatment group was 96.55%,compared with the total effective rate of the control group(89.28%).The difference was statistically significant(P<0.05).5.the two groups of treatment after a course of treatment,serum C-reactive protein,IL-8,TNF-a levels were significantly lower than before treatment,the results were statistically significant(P<0.05).After comparison between groups,the levels of C-reactive protein,IL-8 and TNF-a in the treatment group were slightly lower than those in the control group,and the difference was statistically significant(P<0.05).6.There were no significant changes in vital signs during the treatment of the two groups.The patients who were studied did not have adverse reactions such as digestive tract discomfort.There were no obvious abnormal changes in blood routine,seven liver functions and seven renal functions before and after treatment.Conclusion:The application of Sangzhi Zhike Decoction in the treatment of patients with acute bronchitis and phlegm-heat-lung syndrome can effectively improve the clinical symptoms such as cough and sputum,and it is faster than the simple treatment with western medicine,and the clinical effect is more sig,nificant.At the same time,Mulberry Zhike Decoction can also reduce the occurrence and development of airway inflammation by reducing the number of inflammatory cells in the serum and regulating the number of inflammatory factors.This topic affirms the safety and effectiveness of the use of mulberry and cough in clinical use,and provides a theoretical basis for future treatment options. |
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