Clinical Study Of Yangyin Huyu Tongqiao Decoction In The Treatment Of Non-dementia Vascular Cognitive Impairment Of Cerebral Small Vascular Disease

Objective To observe the effects of Yangyin Heyu Tongqiao decoction on TCM symptom scores,neuropsychology scales MoCA and ADL in patients with cerebral small vessel disease non-dementia vascular cognitive dysfunction,and evaluate their curative effect;compare Hcy,TG,TC,LDL,and FIB,before and after treatment Changes analysis of possible mechanisms of action;assessment of safety.Methods This study included 60 elderly patients who met the diagnostic criteria of non-dementia vascular cognitive impairment of cerebral small vascular disease and the diagnostic criteria of yin deficiency and blood stasis syndrome,including 42 males and 18 females,aged 62-95 years old,randomly being divided,30 into treatment group and 30 into control group,the treatment group was treated with Yangyin Heyu Tongqiao decoction and common western medicine,the control group was treated with nimodipine tablets and common western medicine.The observation time was three months,and the TCM symptom scores and curative effects were evaluated separately.Before and after treatment,patients with MoCA score,ADL score,Hcy,TG,TC,LDL and FIB,statistical analysis of the two groups of treatment results.Results There were no significant differences in age,gender,TCM syndrome scores,MoCA score,ADL score,Hcy,TG,TC,LDL and FIB between the treatment group and the control group(P>0.05).1.TCM syndrome efficacyTCM syndrome scores and curative effect comparison,after treatment,the TCM syndrome scores between the two groups were lower than before,P value was<0.01,there was statistical difference;after treatment,the syndrome scores between the two groups were P<0.01,and the treatment group was significantly more effective.In the control group,the total effective rate(93.33%)was significantly better than the control group(73.33%).In the treatment group,0 cases were cured,9 cases were markedly effective,19 cases were effective,2 cases were ineffective,and 28 cases were effective.In the control group,0 cases were cured,4 cases were markedly effective,18 cases were effective,8 cases were ineffective,and 22 cases were effective.2.Neuropsychological scaleCompared with the control group,the improvement of single cognitive function of MoCA scores before and after treatment,the statistical analysis by paired t test,the naming ability and ion P value>0.05,no statistical difference,visual space and execution ability,attention,language,delayed recall,The orientation force was<0.05,which was statistically significant Among them,visual space and execution ability,attention,delayed recall,and orientation force P value were all<0.01,which were significantly different.The improvement of single cognitive function of MoCA scores before and after treatment in the treatment group was statistically analyzed by paired t-test.P value was<0.05,and there were statistical differences.Among them,visual space and execution ability,attention,delayed recall,and orientation force P value Both were<0.01,with significant differencesThe single cognitive function of the treatment group and the control group before treatment was compared.The P value was>0.05.There was no significant difference between the two groups.After treatment,the single cognitive function of the treatment group and the control group,P value was>0.05.No significant difference.Compared with the ADL scores,the ADL scores were effective in both groups(P<0.01).There was no significant difference in ADL scores between the two groups after treatment(P>0.05).3.Laboratory indicatorsCompared with the previous two groups,the P values were<0.01,which was statistically significant.There was no significant difference in Hey between the two groups after treatment.The levels of TC,TG and LDL were compared.Before treatment,the P values were<0.01,which were statistically significant.The TC,TG and LDL levels and P values were compared between the two groups after treatment.0.05,there is a statistical difference.Compared with the previous FIB levels,the P values were<0.01,which was statistically significant.There was a statistical difference between the two groups after FIB,P<0.05.Conclusions1.Yangyin Heyu Tongqiao decoction can significantly improve the TCM symptoms and signs of:csvd-vcind patients with Yin deficiency and blood stasis.2,Yangyin Heyu Tongqiao decoction can improve the cognitive function of patients with CSBD-VCIND(especially attention,delayed recall,significant effect in orientation),daily living ability;can reduce hyperhomocysteinemiaThe patient’s Hcy level regulates TC,TG,and LDL levels in patients with hyperlipidemia.3,Yangyin Heyu Tongqiao decoction are safe and effective,with no obvious side effects.1.Yangyin Heyu Tongqiao decoction can significantly improve the symptoms and signs of TCM in patients with yin deficiency and blood stasis type CSBD-VCIND.2.Yangyin Heyu Tongqiao decoction can improve the cognitive function of patients with CSBD-VCIND(especially in the visual space and execution ability,attention,delay recall,orientation effect),daily life ability.3.Yangyin Heyu Tongqiao decoction can reduce the level of Hcy in patients with hyperhomocysteinemia,and its mechanism may reduce or eliminate oxygen free radical damage,reduce oxidative stress,and protect endothelial cell function and structure.Reduce cerebral ischemia and hypoxia.4.Yangyin Heyu Tongqiao decoction can regulate the levels of TC,TG and LDL in patients with hyperlipidemia.The mechanism may be related to protecting vascular endothelial cells and function,improving lipid metabolism,regulating blood lipid levels and anti-atherosclerosis.Hardening related.5.Yangyin Heyu Tongqiao decoction can reduce the level of FIB,and its mechanism may be related to anti-platelet aggregation,lowering blood viscosity,degrading fibrin,prolonging clotting time,reducing oxygen free radical damage and protecting nerve cells.6.Yangyin and Qitongtongyu are safe and effective,with no obvious side effects.