Clinical Observation Of Yiqi Yangyin Jiedu Decoction Combined With Chemotherapy In The Treatment Of Advanced Non-small Cell Lung Cancer

Objectives:The combination of yiqiyangyin detoxification prescription and chemotherapy was used for the treatment of advanced non-small cell lung cancer(NSCLC)with both deficiency of Qi and Yin,so as to objectively evaluate the therapeutic effect and safety of this prescription.Methods:A total of 100 patients with advanced qi and Yin deficiency type NSCLC collected from changzhou hospital of traditional Chinese medicine were divided into treatment group(Chinese medicine combined with chemotherapy)and control group(chemotherapy),with a 21-day cycle and 3 cycles of treatment.Relevant data were recorded in time and the efficacy of this prescription was evaluated.Tumor markers,TCM syndrome score,quality of life score,solid tumor efficacy,KPS score,weight change before and after treatment,and laboratory examination were observed,and the data were analyzed by spass22.0 statistical software.Results:1.Comparison of the efficacy of TCM syndromes:after treatment,the scores of patients TCM symptoms were evaluated in the treatment group and the control group:compared with before treatment,the scores of the two groups decreased,among which,the scores of the treatment group decreased more significantly,with statistical significance(P<0.05).There were P<0.05 in cough,sputum blood,expectoration,dry mouth,spontaneous sweating and night sweats between the two groups,and the difference was statistically significant.The score of the treatment group was lower than that of the control group,but the difference was not statistically significant(P>0.05).The total effective rate was 62.5%in the treatment group and 40.4%in the control group,significantly higher than that in the control group(P<0.05).2.Comparison of life quality score of lung cancer:in terms of daily activities,emotions and mobility,there were statistically significant differences within the groups.There were also statistically significant differences between the treatment group and the control group by t test(P<0.05).However,there was no significant difference between the treatment group and the control group in social and family aspects before and after treatment.and there was a statistical difference between the two groups after treatment(P<0.05).In terms of additional attention,the difference between the treatment group and the control group before and after treatment was statistically significant(P<0.05),but there was no statistically significant difference between the groups after treatment3.Comparison of KPS scores:after observing the KPS scores of the patients before and after treatment,according to the changes,it was fo und that the total effective rate of the treat,ment group was 91.67%,while that of the control group was 74.47%.The total effective rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).4.Weight efficacy evaluation:in terms of the weight efficacy of patients in the treatment group,the total effective rate was up to 87.5%,while that in the control group was 76.60%.The treatment group was higher than the control group,but there was no statistical difference(P>0.05).5.Efficacy evaluation of solid tumor:the total stability rate and effective rate of patients in the treatment group reached 89.58%and 25%respectively;The control group total stability factor was 74.47%,effective rate was 1 9.15%.However,by fisher’s precise test,P>0.05 showed no statistical difference,so the two groups had similar efficacy in solid tumor.6.Comparison of tumor markers:CEA,CA199 and CA125 of patients in the treatment group before and after treatment were compared,and the difference was statistically significant(P<0.05),the control group not significant(P>0.05).After treatment,there was no statistical difference between the two groups in the reduction of serum CEA and CA199(P>0.05)by rank-sum test,and there was statistical difference in the reduction of serum CA125(P<0.05).7.Comparison of safety and toxic side effects:according to the test of the "x"square,there was no significant difference between the treatment group and the control group in terms of hemoglobin(HB),platelet(PLT),alanine glutamate transaminase(ALT)and glutamate transaminase(AST),etc.(P>0.05).The WBC between the two groups,nausea,vomiting,diarrhea condition difference was statistically significant(P<0.05).Conclusions:1.Compared with pure chemotherapy,yiqiyangyin detoxification recipe can enhance the efficacy to a certain extent with low toxicity and good safety,and will not significantly increase the risk of bone marrow suppression and hepatorenal toxicity.In addition,the prescription can alleviate the gastrointestinal reaction caused by chemotherapy and improve the patient’s tolerance.2.In terms of tumor treatment,the role of TCM cannot be ignored,especially for patients with advanced lung cancer,the combination of TCM and chemotherapy is beneficial to alleviate the clinical symptoms of patients,improve their quality of life and delay the progress of the disease.