| Objective:To explore the effect and mechanism of different therapeutic times of focused extracorporeal shock wave intervention on bone healing in rabbits with bone nonunion.Methods:Select 60 healthy male New Zealand rabbits(weight and month of age are roughly the same),the rabbit unilateral radial nonunion models were made under aseptic conditions,and randomly divided into groups A,B,C and D,the group A was treated with extracorporeal shock wave therapy 1 time,the group B was treated with extracorporeal shock wave therapy 2 times,the group C was treated with extracorporeal shock wave therapy 3 times,the group D was the control group,and no treatment was done.X-ray observation and immunohistochemical detection were performed after treatment,compare the data between each group and then make statistical analysis.Results:The score of the X-ray callus and the score of the fracture line showed that the score of the treatment group increased with the prolongation of the time of treatment.The score of the same treatment time point in different treatment groups also increased with the increase of the number of times of treatment.The results of immunohistochemistry showed that the expression of BMP-2 in callus at each time point was significantly different between group C and groups A,B and D,group B and groups A and D,group A and group D(P<0.05).Conclusion: In a certain range of treatment,as the number of treatments increased,the effect of extracorporeal shock wave on the nonunion of bone was also enhanced. |
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