The Value Of Incoherent Motion Diffusion Weighted Imaging In The Diagnosis Of Spinal Tuberculosis

Objective:To explore the parameter range and diagnostic value of perfusion fraction,pure diffusion coefficient and pseudodiffusion conefficient in patients with spinal tuberculosis patients by diffusion-weighted imaging with incoherent motion in magnetic resonance voxel.Methods:Eighteen patients in the spinal tuberculosis group and the normal control group were collected,and 36 subjects underwent 3.0T MRI routine and IVIM-DWI sequence scanning.Using the double-index model post-processing software,the IVIM-DWI quantitative f,D,D of the spinal tuberculosis group（the diseased vertebral body,the jumping 2 vertebral body,the intervertebral disc）and the corresponding normal control group（normal vertebral body,intervertebral disc）were obtained.Parametric indicators,the value of the IVIM-DWI parameters（f,D,D*）in the spinal tuberculosis group and the normal control group,and the value of the diagnosis of spinal tuberculosis..Results:（1）The f value of the vertebral body in the spinal tuberculosis group was[12.91（8.15,22.73）%],which was lower than that in the control group[37.16（30.45,47.07）%];（Z=6.841,P<0.001）;D value[0.88（0.73,1.40）x10^-3mm²/s],D*value[39.99（20.15,66.35）x10^-3mm²/s],significantly higher than normal vertebral body D value[0.07（-0.12,0.28）x10^-3mm²/s],D*value[20.37（12.26,29.97）x10^-3mm²/s];（Z=7.598,P<0.001;t=3.842,P<0.001）.（2）Compared with the normal vertebral body f value of the vertebral body of the spinal tuberculosis group,the former was lower than the latter[40.51（33.75,46.28）%],（Z=3.421,P=0.001）;the D values were significantly higher than the former[0.05（-0.20,0.15）x10^-3mm²/s],（Z=3.743,P<0.001）.（3）In the spinal tuberculosis group,the intervertebral disc f value[6.72（4.36,11.53）%],D value[2.06（1.92,2.26）x10^-3mm²/s],were higher than the normal intervertebral disc of the control group[5.72（3.00,7.85）%],[1.88（1.79,1.85）x10^-3mm²/s];（Z=2.276,P=0.023）、（Z=3.919,P<0.001）.The maximum area under the curve for obtaining the D value of the ROC curve is 0.960,the sensitivity is 95.74%,the specificity is 87.56%,and the optimal diagnostic threshold is 0.63x10-3 mm2/s.Conclusion:IVIM-DWI can quantitatively evaluate the diffusion and microvascular perfusion characteristics of diseased water molecules.Through the range of quantitative parameters of f,D and D*in IVIM,D value has the highest sensitivity and specificity for diagnosis of spinal tuberculosis,and provides clinical diagnosis of spinal tuberculosis.A valid range of referencevalues.