The Value Of Intravoxel Incoherent Motion Diffusion Weighted Imaging In Quantitatively Evaluating Of Metastatic Vertebral Disease

Objective:To explore the value of intravoxel incoherent motion diffusion weighted imaging in quantitatively evaluating of metastatic vertebral disease（MVD）.Materials and Method:110 vertebral bodies of twenty one patients with metastatic vertebral disease and103 vertebral bodies with 11 healthy volunteers from June,2018 to Sep,2018,were included as two groups.The conventional MR and IVIM-DWI examination were performed in all patients,IVIM-DWI was performed by using 8 b values（0、50、100、150、200、400、600、800 s/mm²）.To calculate IVIM-DWI parameters（diffusion coefficient[D],pseudo diffusion[D^*],perfusion fraction[f]）and nonparametric test（two independent samples）Mann-Whitney U were performed to compare the statistical significance between D,D^*and f values of two groups.The receiver operating characteristic（ROC）curve was used to evaluate the efficiency of metastatic vertebral disease,and then corresponding the areas under the ROC curve（AUC）,cut-off values,sensitivity and specificity were received.Result:The D,D^*values of the MVD were（0.81±0.44）×10^-33 mm²/s、（55.28±42.12）×10^-33 mm²/s respectively,which higher than those of the group volunteers（1.07±0.24）×10^-3mm²/s,（0.73±0.21）×10^-33 mm²/s.The f value of the group MVD was（0.12±0.07）%,which lower than that of the group volunteers（0.37±0.15）%.Comparison of IVIM-DWI related parameters of spine metastases from different tumor have no statistical significance.There are statistical significance between the two groups（P<0.05）The cutoff value,AUC,sensitivity and specificity of diagnosing MVD were,0.75×10^-33 mm²/s、0.917、86.4%、88.3%for D;0.54×10^-33 mm²/s、0.752、71.8%、81.9%for D^*;f’s were too low to provide the information above.Conclusion:IVIM-DWI quantitative analysis is helpful in the diagnosing of metastatic vertebral disease.The D value afforded a better diagnostic performance than other parameters.