Value Of Bone Metabolism And Bone Mineral Density In Evaluating The Risk Of Postmenopausal Osteoporotic Vertebral Compression Fracture

Objective: To investigate the value of biochemical markers of bone metabolism and bone mineral density in the diagnosis of osteoporotic vertebral compression fractures in postmenopausal women with osteoporosis.Methods: According to the inclusion and exclusion criteria,the clinical data of 269 postmenopausal women with postmenopausal osteoporosis were retrospectively collected in the Subei Hospital.Among postmenopausal osteoporosis women,there are 133 patients with vertebral compression fractures and 136 patients without vertebral compression fractures.Record and observe general information about these patients,including: age,height,weight,BMI,and BMD,serum bone metabolism biochemical indicators: PINP,N-MID,CTX,vitamin D.Analysis of BMD and bone metabolism indicators for the evaluation of osteoporotic vertebral compression fractures in postmenopausal women with osteoporosis.Statistical methods: Statistical analysis was performed using SPSS 24 software.Numerical variables were expressed in the form of Mean ±SD.Comparison between groups was performed by t test(two sets of data were first tested for homogeneity of variance,if the variance is uniform t test was used;If the variance is not uniform,the calibration t test is used).After screening out the statistically significant differences between the groups,the binary logistic regression model was used to analyze the correlation between the indexes and the risk of osteoporotic vertebral compression fractures in postmenopausal women with osteoporosis.P<0.05 has statistical significant.Result: The results of independent sample t-test showed that there were no statistical significant differences in general data(age,height,weight,BMI)between the postmenopausal women with vertebral compression fractures and those without vertebral compression fractures(P>0.05).There was no significant difference in BMD(hip BMD and vertebral BMD)between the two groups(P>0.05).The serum biochemical markers of serum bone metabolism were analyzed in the two groups.The values of the N-MID in the two groups were not significantly different(P>0.05).There are statistical significant differences in the values of PINP,CTX,and vitamin D.(P<0.05).Logistic regression analysis found that: in postmenopausal women with osteoporosis,the occurrence of osteoporotic vertebral compression fracture was positively correlated with the serum concentration of PINP(OR=1.068,95% Cl :1.048-1.089);negatively correlated with serum concentration of vitamin D(OR=0.961,95% Cl: 0.931-0.992);no significant correlation with serum concentration of CTX,(P>0.05).Conclusion: 1.In postmenopausal women with postmenopausal osteoporosis,there is a significant association between the risk of osteoporotic vertebral compression fracture and the bone metabolism markers: PINP and Vitamin D.PINP is a risk factor,and vitamin D is a protective factor.PINP and Vitamin D have application value in assessing the risk of osteoporotic vertebral compression fracture in postmenopausal women.2.There was no significant correlation between bone mineral density and osteoporotic vertebral compression fracture in postmenopausal women with osteoporosis.Bone mineral density combined with bone metabolism indicators may have a greater advantage.