Analysis Of Metabolic Risk Factors In Young Hypertensive Intracerebral Hemorrhage

Objective: To analyze the cases of 360 young patients with spontaneous intracerebral hemorrhage and 97 young patients with primary hypertension,to investigate the relevant metabolic risk factors in young patients with spontaneous intracerebral hemorrhage,and to guide the clinical diagnosis and treatment of hypertension intracerebral hemorrhage in young people.Method: We collected 360 patients with spontaneous intracerebral hemorrhage in our department of neurology and neurosurgery from August 2012 to January 2019,and collected clinical data.87 patients with complete data on intracerebral hemorrhage were selected.At the same time,97 young patients with primary cerebral hemorrhage who were hospitalized in our hospital were selected by simple randomization.The clinical data such as age,sex,smoking history,drinking history,diabetes mellitus,random blood glucose on the day of admission,UA,TG,TC,HDL-C,LDH-C,Apao1,Apob,Apoa1/Apob,Lp(a)were collected.A retrospective analysis method was used to analyze the risk factors of young hypertensive intracerebral hemorrhage patients.Results: 1.Epidemiology: There are 87 young patients with hypertensive cerebral hemorrhage,including 12 females,accounting for 13.79%,75 males,accounting for 83.87%.The higher the age,the higher the prevalence.Among them,the proportion of patients aged 39-45 was the highest,accounting for 79.31%.2.Bleeding sites: 49 cases of basal ganglia,accounting for 56.32%,2 cases of brain stem,accounting for 2.30%,12 cases of external capsule,accounting for 12.80%,8 cases of thalamus,accounting for 10.20%,1 case of cerebellum,accounting for 1.15%,brain There were 12 cases of leaves,accounting for 13.79%,1 case of semi-oval center,accounting for 1.15%,and 1 case of radiation crown,accounting for 1.15%.3.Influencing factors: Results Single factor analysis showed that there is statistical relation between diabetes mellitus(P=0.001),LDL-C(P=0.023),Apo B(P=0.042),LP(P=0.047),diastolic blood pressure(P=0.028)and spontaneous intracerebral hemorrhage.There was no statistically significance between gender(P=0.56),age(P=0.075),smoking(P=0.275),drinking(P=0.464),systolic blood pressure(P=0.954),uric acid(P=0.534),TG(P=0.214),TC(P=0.871),HDL-C(P=0.129),APOa1(P=0.662),APOa1/b(P=0.248)and spontaneous intracerebral hemorrhage.Binary logistic regression model showed diastolic blood pressure as a protective factor for young hypertensive intracerebral hemorrhage.(OR=0.978,95% Cl: 0.959-0.996;P=0.02);diabetes mellitus(OR=3.458,95% CI 1.544-7.746P=0.003)and LP(OR=1.004,95% CI 1.001-1.007;P =0.007)were risk factors for young patients with hypertensive intracerebral hemorrhage.Conclusion: 1.The incidence of cerebral hemorrhage increases with age,and the proportion increases.Young hypertensive cerebral hemorrhage are more common in male than female.2.The bleeding site of young intracerebral hemorrhage is mostly located in deep brain tissue such as basal ganglia,external capsule,thalamus,cerebellum,of which basal ganglia are the most common.3.Diastolic blood pressure is a protective factor for young patients with hypertensive cerebral hemorrhage.diabetes mellitus and lipoprotein are risk factors for young patients with hypertensive intracerebral hemorrhage.4.Intracerebral hemorrhage has high mortality and disability rate.In order to prevent the occurrence of intracerebral hemorrhage,we need to improve our understanding of stroke,strengthen awareness and intervention on risk factors.Note that numerous studies have found that impaired fasting glycaemia,Hb A1 c,diastolic blood pressure and serum lipid level are associated with stroke risk as a J curve or a U curve.So influence factors should not be over-controlled.Only using targeted programs for different groups of people can effectively reduce the burden of stroke on patients and society.