Correlation Between Lymphocyte-monocyte Ratio And Coronary Slow Flow Phenomenon

Objectives: The correlation between lymphocyte-to-monocyte ratio and coronary slow flow was assessed.Methods: During the period from January 2017 to December 2018,60 patients who were hospitalized in the Department of Cardiology of the First Hospital of Handan City and diagnosed with slow coronary flow were selected as the case group.Selected 64 patients who underwent coronary artery angiography at the same time,these patients who coronary artery angiography showed normal coronary artery and blood flow velocity were normal as the control group.Whole blood cell count and classification,fasting blood glucose(Clu),creatinine(Cr),total cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL),and high density lipoprotein(HDL)were measured in the two groups,hypersensitive C-reactive protein(hs-CRP).LMR calculated by calculation.The research data were analyzed by SPSS20.0 statistical software.Results:1.The data of the case group and the control group were statistically analyzed.The results showed that there was no significant difference in gender(male/female),age,smoking,hypertension,diabetes,oral ACEI /ARB,beta-blocker,calcium channel blocker,statin etc.(P>0.05);2.There were no significant differences in the white blood cell count,neutrophil,glucose,Cr,TC,TG,HLD,and LDLbetween the two groups(P>0.05).The number of monocytes and hs-CRP in the slow blood flow group were significantly higher than those in the control group(6.25±0.95 VS6.15±1.38,0.57±0.18 VS 0.47±0.10,1.07±0.83 VS 0.60±0.34,P<0.05),Lymphocyte and LMR results were significantly lower in the case group than in the control group(1.37±0.45 VS 1.64±0.33,2.49±0.69 VS 3.47±0.53,P<0.05);3.In the slow blood flow group,the incidence of single vessel was high(75.00%),and the right coronary artery(RCA)was the most common,accounting for 47.44%;4.According to the measured LMR value,the ROC curve is drawn.The optimal cutoff value of LMR is 2.75,Area under the ROC curve(AUC)is 0.75,the sensitivity is 58.10%,and the specificity is 84.00%.LMR has predictive value for CSFP.With LMR=2.75 as the cut-off value,case groups were divided into low LMR group and high LMR group,therelationship between the level of LMR and the number of CSFP vessels was analyzed;5.According to the results of logistic regression analysis,hs-CRP and low-level LMR were risk factors for coronary slow flow(OR: 0.07,95% CI: 0.02-0.22,P<0.01),and negatively correlated with hs-CRP.Conclusions:LMR decline is a risk factor for CSFP and has a certain predictive value for CSFP.The inflammatory response is involved in the development of CSFP.