Emergent Percutaneous Coronary Intervention In Patients Resuscitated From Out Of Hospital Cardiac Arrest Without ST-segment Elevation:A Meta Analysis

Objective: A meta-analysis of published studies was conducted to assess the impact of emergent percutaneous coronary intervention and delayed or non-intervention on survival and neurological prognosis in patients resuscitated from out-of-hospital cardiac arrest without ST-segment elevation.Methods: A structured search was conducted using PubMed,Embase,the Cochrane Library and Web of Science by two independent investigators using a variety of keywords.Then evaluated the quality of the literature and extracted the relevant data.Random effect model was used to collect data,while funnel plot and Begg’s Test were used to evaluate publication bias,and sensitivity analysis of the results was carried out.Results: Ten studies were included in our meta analysis.The results of meta-analysis showed that emergent coronary intervention could improve the survival rate(OR = 1.58,95% CI = 1.02-2.46)and neurological function prognosis(OR = 1.75,95% CI = 1.05-2.92)of patients resuscitated fromout-of-hospital cardiac arrest without ST-segment elevation.Conclusion: Patients resuscitated from out-of-hospital cardiac arrest without ST segment elevation may benefit from emergent coronary intervention.However,our conclusion still needs more guidance from multi-center,large-sample randomized controlled clinical trials.