Relationship Of Lp-PLA2 And S100? Levels With Carotid Artery Plaque In T2DM With Cerebral Infarction

BackgroundIn China,stroke is the leading cause of death in China,and it has become the first cause of life loss and shortening the length of life.The prevalence of type 2 diabetes mellitus(T2DM)has quadrupled in 30 years since 1980,affecting 422 million adults in 2016.Cerebral infarction is a common type of macroangiopathy in type 2 diabetes mellitus and an important factor in fatal diabetic complications.Diabetic patients have a higher risk of stroke.Compared with people without diabetes,their mortality and disability rates increase.A study shows that among people with diabetes more than 10 years,the risk of ischemic stroke is three times higher than that of non-diabetic patients.Previous data show that carotid artery stenosis is the main factor leading to ischemic encephalopathy,but with the strengthening of evidence-based basis,it has been found that rupture and erosion caused by unstable atherosclerotic plaque play an important role in promoting the occurrence of acute cerebral infarction.ObjectiveThe main purpose of this study is to study the expression level of serum lipoprotein-associated phospholipase A2(Lp-PLA2)and S100? and related inflammatory factors in patients with acute cerebral infarction with type 2 diabetes mellitus and the correlation between the stability of carotid plaque,so as to provide more accurate primary prevention,treatment,improvement of prognosis and secondary pre-treatment for patients with cerebral infarction with type 2 diabetes mellitus.MethodsRetrospectively analyse 252 ACI patients with T2DM(group A)in our Neurology Department,which consist of unstable plaque 128,stable plaque 84,no-plaque 40.While 120 patients with acute cerebral infarction were selected as group B.120 eld er people were selected as the control group C.NIHSS scores and infarction volum e were calculated in the ACI patients.The levels of Lp-PLA2,IL-1?,IL-6,S100 B blood glucose and glycosylated hemoglobin were detected on the next day of admis sion,and the statistical significance was analyzed.Results1.The levels of Lp-PLA2,IL-1? and IL-6 in group A were higher than those in group B and C,The same result is seen in group B and C.The difference was statistically significant(P<0.05);The NHISS scores and cerebral infarction volume and S100? level in group A were higher than in group B(P<0.05).2.In group A,the unstable plaque group had a higher level of Lp-PLA2,IL-1?,IL-6,S100?,fasting blood glucose(FBG)and glycosylated hemoglobin than these indexes in stable plaque and no-plaque group(P<0.05).3.The character of carotid plaque in group A was positively correlated with FBG,2 hours postprandial blood glucose,glycosylated hemoglobin,Lp-PLA2,IL-1B,IL-6;Conclusion1.Patients with type 2 diabetes cerebral infarction have higher inflammatory levels and more severe neurological deficits.2.The patient's poor control of blood glucose levels is associated with plaque stability.3.Lp-PLA2,IL-1?,IL-6 and S100? can provide reference for early disease assessment,clinical treatment and prognosis of type 2 diabetes patients.