Clinical Analysis Of Donor-related Risk Factors For Delayed Graft Function After DCD Kidney Transplantation

Objective:The incidence of delayed graft function(DGF)in donation after cardiac death(DCD)kidney transplantation is higher than other donor types.DGF has many influencing factors and complicated mechanism.The purpose of this study was to determine donor-related risk factors for DGF in DCD kidney transplantation in order to facilitate early effective interventions to promote graft function recovery.Methods:A total of 60 cases of DCD kidney transplantation were collected and divided into DGF group(n=19)and non-DGF group(n=41)according to whether DGF occurred in recipients after kidney transplantation.Variables were considered candidate risk factors for DGF,and univariate and multivariate logistic regression were used to determine donor-related risk factors and independent risk factors for DGF,P < 0.05.Results:The incidence of DGF is 31.7%.In the univariate analysis,these donor-related variables showed significant differences(P < 0.05): age(DGF group,43.3 ± 18.6years;non-DGF group,32.3 ± 16.5 years),body mass index(BMI)(DGF group,26.5± 2.4 kg/㎡;non-DGF group,21.2 ± 4.6 kg/ ㎡),terminal serum creatinine value(DGF group,284.6 ± 193.9 μmol/L;non-DGF group,70.1 ± 74.3 μmol/L),history of hypertension(DGF group,26.3%;non-DGF group,7.3%),cause of death(brain Vascular disease: DGF group,42.1%;non-DGF group,9.8%);only the hospitalization time in the recipient-related variables(DGF group,21.5 ± 7.2 days;The non-DGF group,17.7 ± 5.1 days)showed significant differences(P < 0.05).Multivariate analysis identified donor-independent risk factors for DGF in DCD: BMI(P = 0.045)and terminal serum creatinine(P = 0.031).Conclusions:Donor-related risk factors for DGF in DCD kidney transplantation were age,BMI,terminal serum creatinine value,history of hypertension,and cause of death.Independent risk factors were BMI and terminal serum creatinine value,and with the increased in donor BMI and terminal serum creatinine value,the incidence of DGF was also increased;DGF recipients were hospitalized significantly longer than non-DGF recipients.