A Comparative Study On The Prevention Of Chemotherapy-related Nausea And Vomiting Between Paronosetron Combined With Chlorpromazine And Paronosetron Combined With Methoxychlorpromide

objectives:On the basis of paronosetron,the difference of curative effect between chlorpromazine and methoxychlorpromide in preventing chemotherapy-related nausea and vomiting was analyzed.methods:240 solid tumor patients who received medium to high emetogenic chemotherapy were randomly assigned to the experimental group and the control group.The antiemetics regimen of the experimental group was: palonosetron injection + chlorpromazine hydrochloride injection.The antiemetic regimen in the control group was: palonosetron injection + methoxyclopramide hydrochloride injection.All patients were treated with conventional care during hospitalization.The primary endpoint of the study was the incidence of nausea and vomiting in the acute phase and the delayed phase,and the secondary endpoint was the quality of life of the patients during chemotherapy and the incidence of adverse reactions to the two drugs.results:A total of 240 patients were enrolled from March 2017 to January 2019.1.The incidence of acute nausea was 74.2% in the control group and 60.0% in the experimental group,with statistically significant differences(P<0.05).The incidence of delayed nausea was 69.2% and 51.7%,respectively,with statistically significant difference(p<0.05).The incidence of acute vomiting was 65.9% and 47.5%,respectively,and the difference was statistically significant(P<0.05).The incidence of delayed vomiting was 55.8% and 35.8%,respectively,and the difference was statistically significant(P<0.05).2.The total FLIE score of the experimental group and the control group during chemotherapy was 110.91 and 106.02,respectively.The number of patients with >108 in the experimental group was 72,and the number of patients with >108 in the control group was 53,and the difference was statistically significant(p<0.05).3.The main adverse reactions of the two groups were dizziness,weakness and drowsiness,and the probability of adverse reactions was not statistically significant(p>0.05).conclusion:joint parlour,chlorpromazine hydrochloride SiQiong anti-nausea scheme with amine methoxychlor tome parlour SiQiong compared anti-nausea schemes,nausea and vomiting in the acute phase of prevention,delay has good curative effect,can improve the life quality of patients during chemotherapy,and will not increase adverse reactions,worthy of clinical popularization and application.