Relationship Between Helicobacter Pylori Infection And Different Pathological Types Of Colonic Polyps

Objective:Helicobacter pylori（Hp）has been listed as the first category of carcinogen in gastric cancer by the world health organization.In recent years,with the deepening of the research on helicobacter pylori by domestic and foreign scholars,it has been shown that helicobacter pylori infection is not only the main pathogenic factor of gastric cancer,but also related to other parts of gastrointestinal tumors.In particular,the correlation between colorectal polyps or colorectal cancer and helicobacter pylori infection has become a hot topic of current research.Most domestic and foreign scholars believe that helicobacter pylori infection is a risk factor for the occurrence and development of colorectal polyps and colorectal cancer,but a few scholars hold the opposite view.There is no consensus on the correlation between the two.This study will analyze the correlation between helicobacter pylori infection and different pathological types of colorectal polyps,so as to provide some help for the prevention and treatment of colorectal tumors.Methods:Patients admitted to the fourth affiliated hospital of nanchang university from June 2016 to August 2018 were examined by electronic gastroscopy,electronic colonoscopy and¹³C-urea breath test or rapid urease test.According to the inclusion and exclusion criteria,150 patients in the colorectal adenomatous polyp group,150patients in the hyperplastic polyp group and 150 patients in the inflammatory polyp group were included.Another 150 patients with no abnormal results of electronic colonoscopy were collected as the control group.Case data were collected for analysis,gender differences in each group were analyzed by chi-square test,and age differences in each group were compared by single factor analysis of variance.The infection rates of helicobacter pylori in each group were retrospectively analyzed,and the difference of helicobacter pylori infection rate between the experimental group and the control group was analyzed by chi-square test.Grouping according to different detection methods of helicobacter pylori,the chi-square test was used to compare the infection rates of helicobacter pylori between the groups of adenomatous polyps,hyperplastic polyps,inflammatory polyps and the control group.The groups with different infection rates of helicobacter pylori were divided into left half colon group and right half colon group according to the growing site of polyps,single group and multiple group according to the number of polyps,<1cm group and≥1cm according to the maximum diameter of polyps.Then comparing the difference of helicobacter pylori infection rate in each subgroup.Results:The gender and age distribution of colorectal adenomatous polyp group,proliferative polyp group and inflammatory polyp group were not statistically significant compared with the control group（all P<0.05）.The infection rate of helicobacter pylori was 62.67%（94/150）in the adenomatous polyp group,52.67%（79/150）in the hyperplastic polyp group,48.67%（73/150）in the inflammatory polyp group,and 46.67%（70/150）in the control group.The infection rate of helicobacter pylori in patients with colorectal adenomatous polyps was statistically significant compared with that in the control group（χ²=7.747,P<0.05）.The infection rate of helicobacter pylori in the hyperplastic group and the inflammatory polyp group was higher than that in the control group,but the difference of helicobacter pylori infection rate was not statistically significant（χ²=1.08,0.12,all P>0.05）.Different methods for detection of helicobacter pylori infection by¹³C-urea breath test and rapid urease test were used for grouping.Under the two methods,the infection rate of helicobacter pylori in the adenomatous polyp group was compared with that in the control group,and the difference of helicobacter pylori infection rate was statistically significant（χ²=4.658,4.624,all P<0.05）.However,the infection rates of helicobacter pylori in the inflammatory polyp group and the hyperplastic polyp group were not statistically significant compared with those in the control group（all P>0.05）.The colorectal adenomatous polyp group was grouped according to the location of polyp growth,the number of polyps and the maximum diameter of polyps.The infection rates of helicobacter pylori were 66.1%in the left half colon group and 51.4%in the right half colon group,but the difference of helicobacter pylori infection rate was not statistically significant（χ²=2.464,P=0.116>0.05）.The infection rate of helicobacter pylori was 60.4%in single group and 63.9%in multiple group,but the difference of helicobacter pylori infection rate was not statistically significant（χ²=0.184,P=0.668>0.05）.The infection rates of helicobacter pylori were 58.0%in the<1cm group and 66.7%in the≥1cm group,but the difference of helicobacter pylori infection rate was not statistically significant（χ²=1.204,P=0.273>0.05）.Conclusion:1.Colorectal adenomatous polyps were associated with helicobacter pylori infection,while inflammatory polyps and hyperplastic polyps of the colorectum were not associated with helicobacter pylori infection.Therefore,it is concluded that helicobacter pylori infection increases the risk of adenomatous polyps in the rectum,and it is suggested that patients with helicobacter pylori infection should be screened for early colorectal tumors.2.Whether helicobacter pylori was detected by¹³C-urea breath test or rapid urease test,both suggested that helicobacter pylori infection was associated with colorectal adenomatous polyps,but not with colorectal inflammatory polyps and colorecta hyperplastic polyps.3.Helicobacter pylori infection has no correlation with the growth site,number and size of colorectal adenomatous polyps.