| Background and ObiectivesCervical cancer is one of the most common malignant tumors in the human body and ranks first in gynecological tumors.In recent years,the universal application of the "three-step" technique and treatment of cervical cancer has enabled early detection and treatment of cervical cancer and precancerous lesions,and the incidence and mortality of cervical cancer have decreased significantly.The main path of cervical cancer metastasis is direct spread and lymph node metastasis.Hematogenous metastasis is rare.It usually spreads directly into the local infiltration of cancerous tissues and directly spreads to adjacent organs and tissues.It often involved in the vaginal wall,rarely involving the uterine cavity up the cervical canal.In the current stage of the Federation of Gynecology and Obstetrics(FIGO),it is usually impossible to estimate whether cervical cancer invades the uterus.Therefore,whether cervical cancer invades the uterus during staging is not considered,but after surgery,Patientswith cervical cancer can be diagnosed by pathology whether the uterus is infiltrated.Some studies have reported that cervical cancer infiltration is an important factor affecting prognosis.Ki-67 antigen can accurately reflect the proliferative activity of cells to judge the malignancy of different types of tumors to predict the prognosis of patients.P63 is widely and selectively expressed in human tissues and is important for the formation of normal epithelium.It may play a role as a tumor suppressor gene,participate in tumorigenesis and inhibit apoptosis.This study was designed to analyze the age of onset of cervical cancer in patients with uterine infiltration and non-uterine infiltration,FIGO clinical stage of cervical cancer,the pathological type of tumor,the depth of cervical invasion,lymph node metastasis,and the expression of Ki-67 and P63 in postoperative pathological reports.The situation was analyzed to analyze the clinical features of uterine infiltration of cervical cancer.Materials and Methods:All patients with pathological reports after undergoing gynecological surgery at the Second Affiliated Hospital of Zhengzhou University from August 2012 to December2016 and receiving pathological examination after surgery were enrolled.A total of275 patients were included.There were 18 cases of cervical cancer and 257 cases of non-uterine infiltration.A retrospective cohort analysis was performed to compare the general data(age,FIGO clinical stage),surgical related indicators(surgery time,intraoperative blood loss,postoperative complications),pathological data(histopathon type,The depth of infiltration,lymph node metastasis,Ki-67,P63expression),analysis of clinical features of patients with uterine infiltration of cervical cancer.Results:1.There were no significant differences in the age(48.0±10.3 vs 56.1±11.2),operation time(286.6 ± 69.4mins vs 283.5 ± 73.6mins),intraoperative bloodloss(315±79ml vs 289±70 ml),,FIGO clinical stage and postoperative complications between the two groups(P>0.05).2.The non-squamous cell rate(38.9%),cervical infiltration depth(33.3%),lymph node metastasis rate(44.4%)and Ki-67 positive expression(72.2%)in the uterine infiltration group were higher than those in the non-uterine infiltration group of 9.7%、14.8%、14.9%、47.9%.The difference was statistically significant(P<0.05).3.The positive expression of P63 in the uterine infiltration group was lower than that in the non-uterine infiltration group(P<0.05).Conclusion:1.Cervical cancer with uterine infiltration or not,has no relationship with the age of onset,cervical cancer FIGO clinical stage.2.In the immunohistochemical results of uterine infiltration of cervical cancer,the positive expression rate of Ki-67 was increased and the positive expression of P63 was decreased.3.In the pathological results of Uterine infiltration of cervical cancer non-squamous cell carcinoma has a higher proportion,and it is more prone to deep infiltration of the cervix,and the lymph node metastasis rate is significantly increased.Cervical cancer with infiltration of the uterus is more malignant and more invasive. |
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