| Background:In current world,the number of patients with diabetes mellitusis is increasing,and the disease has already caused a threat to the health of all human beings.Among many types of diabetes mellitusis,type 2 diabetes mellitusis is the largest number of one type in diabetes mellitusis patients,its total proportion can reach more than 90%.Diabetic peripheral neuropathy is one of the most common chronic complications in diabetes mellitusis.Its pathogenesis is complicated,and today’s treatments to it are not ideal.Therefore,it is imperative to find new treatments with obvious curative effects and small side effects for the disease.The theory of "medicine and food homology" in traditional Chinese medicine has made an indelible contribution to contemporary nutrition,health care,and natural plant pharmacology.The flour of edible medicinal food in this study is based on this theory,and specially formulated according to the disease characteristics of patients with diabetic peripheral neuropathy.It is mainly composed of a variety of medicine and food homologous plant components with hypoglycemic,lipid-lowering,improved microcirculation,anti-oxidative stress,inhibition of sorbitol accumulation in nerve cells,etc.Purpose:To observe the efficacy of flour of edible medicinal food on patients with diabetic peripheral neuropathy for providing a new direction in the treatment of diabetic peripheral neuropathy.Method:From December 2016 to March 2018,screened 80 patients with diabetic peripheral neuropathy in Department of Endocrinology,Second Hospital of Jilin University,and their ages were from 40 to 74 years old,48 males and 32 females of them with body mass index(BMI)ranging from 24.0 to 28.0.During the treatment period of 3 months,80 patients were randomly divided into the experimental and control groups,40 cases in each group(n = 40).Among them,there were 17 females and 23 males in the experimental group,and 15 females and 25 males in the control group.During the treatment period,every patient was given with scientific treatment such as diabetic diet and exercise guidance,and hypoglycemic drug use.Based on this,the patients in the control group were received with oral mecobalamin tablets(0.5 mg/time,3 times/day);those in the experimental group taken with flour of edible medicinal food(10 g/time,2 times/day)using hot water brewed into the drink.The indices tested before and after 1 and 3 months of treatment were as follows: fasting blood glucose(FPG),2-hour postprandial blood glucose(2h PG),glycosylated hemoglobin(Hb A1c),triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),blood homocysteine(Hcy),liver and kidney function,nerve conduction velocity of phrenic nerve and common peroneal nerve,as well as the Toronto clinical scoring system(TCSS).Result:1.Eighty patients who met the criteria initially were collected in the study,40 cases in each group.During the study,3 patients were decomposed for different reasons.The number of effective patients collected at the end were 77 cases,including 38 cases in the control group and 39 cases in the experimental group.There was no significant difference in the basic data between the two groups(P > 0.05).2.After 3 months of treatment,the levels of FPG,2h PG and Hb A1 c in the two groups were all lower than those before treatment(P < 0.05).Hypoglycemia developed by the patients in the experimental group was more significantly than that in the control group(P < 0.01).3.After 1 month of treatment,the blood lipid and Hcy levels of the patients in the control group were not significantly different from those before treatment(P > 0.05).The changes of TC and LDL-C of the patients in the experimental group were statistically different from those before treatment(P < 0.05).The change of TC in the patients was statistically different from that in the control group(P < 0.05),but the changes of TG,HDL-C and Hcy in them in the experimental group were not significantly those before treatment,and there was no statistical difference(P > 0.05).After 3 months of treatment,The changes of TG,TC,LDL-C and Hcy of the patients in the control group were significantly lower than those before treatment(P < 0.05).The changes of blood lipid and Hcy of the patients in the experimental group were statistically different from those before treatment(P < 0.05).There was a statistically significant difference between the experimental and control group in blood lipid index in the patients(P < 0.05).4.After 1 month of treatment,as compared with those before treatment,the nerve conduction velocity of the patients in the control group increased and the TCSS score decreased.Except for the sensory nerve conduction velocity of common peroneal nerve(P > 0.05),other indexes were statistically different from those before treatment(P < 0.05).The differences between the indices of the patients in the experimental group and the pre-treatment were statistically significant(P < 0.05).After 3 months of treatment,the indices of the patients in the two groups were statistically different from those before treatment(P < 0.05),and the experimental group was statistically different from the control group.(P < 0.05).Conclusion:1.The flour of edible medicinal food can significantly reduce the TCSS score of the patients with diabetic peripheral neuropathy,increase their nerve conduction velocity,and has a significant therapeutic effect on diabetic peripheral neuropathy.2.The possible mechanism of the flour of edible medicinal food in the treatment of diabetic peripheral neuropathy is that insulin resistance,anti-oxidative stress,anti-inflammatory,protecting vascular endothelial cells,etc.were improved by hypoglycemic,regulating blood lipids and homocysteine and other metabolic disorders to control the occurrence and development of the diseases. |
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