Effect Of Shangzhongxiatongyongtongfengfang On Serum Unic Acid And Urine Alpha 1 Microglobulin In Hyperuricemia Mice

Objective: To observe the experimental indexes of hypoglycemia in liver tissue of mice with hyperuricemia,such as XOD,hyaluronic acid,uric acid,urinary ?2 microglobulin,and urine ?1 microglobulin.To observe the effect of the upper and lower general gout on the pathological morphology of the kidneys and to investigate the therapeutic effect of upper and lower general gout on hyperuricemia.Experimental method: The mice involved in the experiment were divided into five groups according to a random method.According to its experimental methods,they were blank control group,model experimental control group,Benxiumalong control group(referred to as phenylbromalon group),upper and lower general gout experimental group(upper and lower general gout group),and allopurinol control group.Group(referred to as allopurinol group),In addition to the blank control group,for the purpose of establishing a continuous hyperuricemia mouse animal model,the rest of the experimental group adopted the method of uric acid enzyme inhibitor potassium oxazine combined with adenine lavage,and the modelling period was 21.In the 7D at the beginning of the research experiment,different intervention drugs were given according to the group.In the 22 nd of the experiment,XOD,hematuric acid,uric acid,and urine ? 1 microglobulin were detected in the liver tissue of the mouse.,urine? 2 microglobulin and other indicators,The pathological changes of kidney in mice were observed.Microglobulin and other indicators,and observe the pathological changes of mouse kidney.ExperimentalResults: The upper and lower general gout prescriptions have the effect of reducing the liver tissue of hyperuricemia mice XOD,hematuric acid,urine? 1 microglobulin,urine? 2 microglobulin,and have a significant effect on elevated uric acid.It shows that the upper and lower general gout prescription has the effect of inhibiting uric acid generation and excretion of uric acid.In pathology,the upper and lower general gout prescription has the effect of reducing the damage of renal tubules and reducing the infiltration of renal interrenal cells.Experimental conclusions: The upper and lower general gout prescriptionscan effectively reduce XOD,hematuric acid,urine ? 1 microglobulin,and urine ? 2 microglobulin in liver tissues of hyperuricemia mice,and have the effect of elevated hyperuricemia mice.uric acid,It can promote the excretion of uric acid in hyperuricemia mice and improve the metabolism of uric acid in hyperuricemia mice.At the same time,it can improve the pathological damage of the kidneys in hyperuricemia mice,and thus play a role in preventing and controlling hyperuricemia.