Clinical Study Of Traditional Chinese Medicine Iontophoresis Combined With Liu Wei Bu Qi Granule In The Treatment Of Patients With Stable COPD

Objective To observe the effect of Traditional Chinese Medicine(TCM)iontophoresis combined with Liuweibuqi granule on the times of acute exacerbation,TCM syndrome score,quality of life assessment scale(COPD Assessment Test),lung function,IL-10,IL-17,TNF-? and VEGF in patients with syndrome of deficiency of lung and kidney qi,phlegm and blood stasis blocking lung in stable Chronic Obstructive Pulmonary Disease(COPD).It is the aim that exploring the clinical efficacy of TCM iontophoresis combined with Liuweibuqi Granule in the treatment of patients with syndrome of deficiency of lung and kidney qi,phlegm and blood stasis blocking lung in stable COPD.Methods 1.In this study,random and parallel control methods were used.80 patients with syndrome of deficiency of lung and kidney qi,phlegm and blood stasis blocking lung in stable COPD were selected from three health medical Institutions,including the First Hospital of Anhui University of Chinese Medicine,the Second Hospital of Anhui Medical University and Sanlian Street Community Health Service Center.The patients were randomly divided into the treatment group(n=40)and the control group(n=40).The control group was treated with basic western medicine(Salmeterol tikacin powder inhaler,50?g/250?g).On this basis,the treatment group was treated with TCM iontophoresis and Liuweibuqi granule.The patients in both groups were treated for 2 months and followed up for 10 months.The study was completed for a total of 12 months.2.The changes of lung function,TCM syndrome scores,CAT before and after treatment were observed.The expression levels of IL-10,IL-17,TNF-? and VEGF in peripheral serum blood were determined by ELISA.The times of acute exacerbation were observed 1 year before treatment and 1 year after treatment initiation.Results The spss24.0 statistical software was used for data analysis and processing.In this study,80 patients were included.Among that,7 Patients were shedding,and 73 patients were effectively studied,including 36 patients in the treatment group and 37 patients in the control group.The general data of the two groups included gender,age,marriage,ethnicity,occupational environment,living environment,education level,exposure history of risk factors and severity of the disease were no difference,and were comparable(P>0.05).1.The impact on the times of acute exacerbation.Before and after treatment,in the treatment group and the control group,the times of acute Exacerbation were significantly decreased(P<0.05),indicating that the two groups were effective.There was no significant difference between the two groups before treatment(P>0.05)while there was significant difference after treatment(P<0.05).2.The impact on the curative effect of TCM syndrome.After treatment,2 patients were markedly effective,30 parents were effective and 4 patients were ineffective in the treatment group,and the totally effective rate was 88.89%;24 patients were effective,13 patients were ineffective in the control group,and the totally effective rate was 64.86%.The rank sum test was used to compare the two groups.The difference is statistically significant(P<0.05).3.The impact on the syndrome score of TCM.There was no significant difference in TCM syndrome score between the two groups before treatment(P>0.05).After treatment,the score of TCM syndrome in the two groups was lower than that before treatment(P<0.05),and the decrease in the treatment group was greater than in the control group(P<0.05).Among the single TCM syndrome scores,the scores of each syndrome in the treatment group were significantly lower than those before treatment(P<0.05).In the control group,there was no significant difference in tongue quality,cold fear of cold limbs, spontaneous sweating and soreness and weakness of waist and knees after treatment(P>0.05).Excepting that,other syndrome scores were statistical significance(P<0.05).There was no significant difference in syndrome scores between the two groups before treatment(P>0.05).After treatment,there was no significant difference in the scores of syndromes between the two groups except panting and wheezing(P>0.05).There was significant difference in the scores of other syndromes(P<0.05).4.The impact on the lung function.Compared with the lung function group before and after treatment,the FEV1%pred and FEV1/FVC% in the control group were slightly lower than those before treatment.The FEV1%pred and FEV1/FVC% in the treatment group were increased compared with before treatment.But before and after treatment in the two groups,there was no significant difference between the treatment group and the control group(P>0.05).5.The impact on the CAT.After treatment,the CAT of the two groups were decreased,and the treatment group was statistically significant(P<0.05).The control group was statistically significant(P<0.05).There was no significant difference in CAT scores between the two groups before treatment(P>0.05).There was significant difference after treatment(P<0.05).6.The impact on the serum indicators.Compared with before and after treatment,the expression levels of IL-10,IL-17,TNF-? and VEGF in peripheral serum blood were decreased,and the difference was statistically significant(P<0.05).There was no significant difference between the two groups before treatment(P>0.05),and there was statistical significance after treatment(P<0.05).Conclusion 1.The treatment of TCM iontophoresis combined with Liuweibuqi granule can reduce the times of acute exacerbation,delay the decline trend of lung fun ction,improve the clinical symptoms of patients,and improve the quality of life.2.The treatment of TCM iontophoresis combined with Liuweibuqi Granules can significantly increase the expression levels of IL-10 and decrease the expression levels of IL-17,TNF-? and VEGF.3.The treatment of TCM iontophoresis combined with Liuweibuqi Granules is safety.There is no adverse reactions occurred in the course of treatment.