Retrospective Analysis Of10,182 Cases Of Lung Cancer

Objective To explore the fiber bronchoscope technological application value in diagnosis of lung cancer.To retrospectively study these characteristics from gender,ages,clinical symptoms and imaging features in lung cancer patients.To analyze the relation between the histologic types and the microscopical characteristics and the relation between the histologic types and the bronchoscopic distribution.To acquire the variation tendency of histologic types,the bronchoscopic distribution,microscopical characteristics.To preliminarily acquire epidemiological characteristic of lung cancer.Methods Retrospectively analyze the clinical data of 10,182 cases of lung cancer diagnosed by histopathology,cytology and immunohistochemistry after sampling by fiberoptic bronchoscopy and other techniques in the department of respiratory medicine of our hospital since January 1,2002 and December 31,2016.Analyze acquired data by means of statistical software SPSS22.0.Results(1)This study found that lung cancer in male patients was significantly higher than that in female patients(P=0.000),and the distribution of lung cancer in patients aged 50-79 years was significantly higher than that in other age groups(P=0.000).The histological type of lung cancer was highest in squamous cell carcinoma,accounting for 44.3%.(2)In this study,the proportion of hyperplasia type was the highest(46.9%),followed by invasive type(21.6%).Squamous cell carcinoma was the most common type of hyperplasia type,invasive type and mixed type,significantly higher than adenocarcinoma and small cell lung cancer(P=0.000).Lung adenocarcinoma was mainly for "normal" type(P=0.000).Lung cancer mainly distributed in double upper lobes,significantly higher than other locations(P=0.000).(3)The variation tendency of histological types of lung cancer in past 15years: the proportion of squamous cell carcinoma is decreased,while the proportion of lung adenocarcinoma is increased(P=0.000).The variation trend of microscopicalcharacteristics of lung cancer: the proportion of hyperplasia type and mixed type were decreasing,while the proportion of "normal type" and infiltration type were increasing with statistical difference(P=0.000).The distribution of squamous cell carcinoma tended to decrease in the double upper lobe and increase in the double lower lobe(P=0.000).The distribution of double upper lobe and double lower lobe of adenocarcinoma showed an upward trend(P=0.000).The bronchoscopic distribution of left main bronchus,double upper lobe,right middle lobe and left lower lobe of small cell lung cancer showed an upward trend,while the distribution of right lower lobe showed a downward trend(P=0.000).(4)Transbronchial biopsy and bronchial brushing have different diagnostic advantages for different histological types and microscopic types of lung cancer;Combined sampling had a significantly higher positive rate than single sampling(P=0.000).For the two different cytological methods,the positive rate of smear cytology was significantly higher than that of liquid-based cytology(P=0.000).Conclusion Fiberoptic bronchoscopy is an important technique for the diagnosis of lung cancer.The epidemiological characteristic of lung cancer in the past 15 years is that the proportion of squamous cell carcinoma is decreasing,while the proportion of lung adenocarcinoma is increasing that is becoming main histological type at present.According to the microscopical characteristics of lung cancer,the proportion of hyperplasia type and mixed type was decreased,while the proportion of "normal type" and invasive type was increased.The bronchoscopic distribution of lung cancer varies with different histological types.