Correlation Between HBV-DNA Load And HCC Syndrome And Influencing Factors Of HCC Spleen Deficiency Syndrome

ObjectiveBased on the literature research,this study analyzed the symptom manifestations and HBV-DNA carrier levels of patients diagnosed with hepatocellular carcinoma in the first diagnosis,compared the distribution patterns of TCM syndromes with different BCLC stages,and explored the liver under different HBV-DNA loading levels.The incidence of spleen deficiency syndrome in cell carcinoma and the related influencing factors of spleen deficiency syndrome.Method1.Collection of cases diagnosed as hepatocellular carcinoma at the first clinic of the First Affiliated Hospital of Guangzhou University of Chinese Medicine from November 10,2014 to December 10,2018.After exclusion,collect general information,symptom manifestations,medical history,laboratory test indicators(including Child-pugh score,AST,ALT,AFP,AFU,HBV-DNA,etc.),imaging data(including CT,MR and PET-CT),histopathological results of pathological differentiation.Firstly,the included cases were divided into three groups:low-load group,medium-load group and high-load group according to the HBV-DNA load level.The differences in gender,age,blood type,BCLC stage,and each group were compared.Distribution pattern of syndromes after different BCLC stages.Then,the included cases were divided into spleen deficiency syndrome group and non-spleen deficiency syndrome group according to TCM syndrome type.The BCLC stage,cancer tissue gross classification,pathological differentiation degree,Child-Pugh score,portal system tumor thrombus and liver were compared between the two groups.Differences between hardening related indicators and related biochemical indicators.All the above research factors were included in the binary logistic regression analysis,and the independent influencing factors affecting the spleen deficiency of the patients were obtained.2.Statistical methods:According to the type of data collected,STATA 12.0 statistical software was used,and the count data was expressed as a percentage.The difference was statistically significant at P<0.05.Correlation analysis between different prognostic indicators and spleen deficiency syndrome and non-spleen deficiency syndrome was carried out according to the 2 test or Fisher exact probability method.The relevant indicators were included in the binary logistic regression analysis,and the independent influencing factors affecting the spleen deficiency syndrome were obtained.Result1.In the study of the distribution of TCM syndrome types,a total of 160 eligible cases were included in the study.Qualified cases included:1 low-load group:41 cases;2 medium-load group:43 cases;3 high-load group:77 cases.The statistical results showed that there was no significant difference in the distribution of TCM syndrome differentiation type of hepatocellular carcinoma under different HBV-DNA load levels.The proportion of liver and kidney yin deficiency was the lowest in the four stages,and the D stage was in the four stages.least.Different HBV-DNA load levels were significantly different from age,in different BCLC stages.The average age in each group was over 50 years old,and the proportion of males was much higher than that of females.The most common type 0 cases were in the blood type,and the least in type AB cases.2.Univariate analysis,hepatocellular carcinoma spleen deficiency syndrome and non-spleen deficiency syndrome in the liver cancer tissue gross classification,BCLC staging,whether accompanied by cirrhosis,Child-Pughscore,whether with portal vein and/or branch tumor thrombus,whether accompanied There were statistical differences in the group of metastases,and the degree of histopathological differentiation,a-L fucosidase,alpha-fetoprotein,and alpha-fetoprotein increased in liver lesions.There was no significant difference in the elevation of aspartate aminotransferase and alanine aminotransferase.In the binary logistic regression analysis,cirrhosis,CHild score and gross classification were statistically different.ConclusionIn this study,there were no significant differences in the levels of HBV-DNA load in stage A,B,C,and D of hepatocellular carcinoma in the BCLC stage,and there were significant differences in age.Cirrhosis,Child-Pugh score and gross classification are the key factors leading to spleen deficiency in patients.Cirrhosis is an independent risk factor for spleen deficiency.The higher the Child-Pugh score,the more likely the patient is to have spleen deficiency and nodular liver cancer.BCLC staging,whether with portal vein and/or branch tumor thrombus,with or without metastases have a certain impact on the occurrence of spleen deficiency syndrome,but the difference was not statistically significant.The pathological differentiation of tumor tissue,the increase of a-L fucosidase,the increase of alpha-fetoprotein,the elevation of alanine aminotransferase and the elevation of aspartate aminotransferase had no significant effect on the occurrence of spleen deficiency syndrome.