Clinical Spectrum Of 26 Children With Bartter Syndrome

Objective:By analyzing the clinical data of children with Bartter syndrome combined with relevant literature,we summarized the clinical manifestations,diagnosis and treatment of BS in children.So we can increase the awareness of pediatricians and achieve the objective of early diagnosis and treatment and improve the prognosis of patients.Methods:Clinical data of 26 patients with Bartter syndrome treated in The Children Hospital of Zhejiang University School of Medicine between 2013-2018 was analyzed retrospectively.Results:The clinical symptom of 26 children with BS is various,including growth retardation,vomiting,polydipsia,polyuria,fatigue,poor appetite.Laboratory examination revealed different levels of hypokalemia,hypochloremia,metabolic alkalosis,the activation of the rennin-angiotensin-aldosterone system.Treated with potassium,indomethacin,spironolactone,these patients’ clinical manifestations and their life quality have been well improved.Conclusion:Bartter syndrome should be considered when children suffer from growth retardation and hypokalemia hypochloremia and metabolic alkalosis.The disease can be clinically diagnosed based on clinical manifestations.Genetic analysis is the most reliable way to make a confirmed diagnosis.Treatment with potassium supplementation,spironolactone and indomethacin,the symptoms of the patients were significantly relieved and the overall prognosis was good.