Effect Of RTMS On Patients With Mild Cognitive Impairment After Stroke And Analysis Of RMT Value

Objective:To observe the effect of different frequency repeated transcranial magnetic stimulation(rTMS)on mild cognitive impairment after cerebral infarction and to observe RMT changes.Materials and methods:collected from January 2017 to June 2018 of suffering from cerebral infarction admitted in our hospital during the period of rehabilitation medicine and merge of 75 patients with mild cognitive dysfunction,according to the order in hospital were randomly divided into observation group and control group,the observation way in subdivision of 0.5 Hz,the 1 Hz group,5 Hz group,10 Hz,the other selected at the same time in the hospital patients as control group,15 cases of patients in each group.the observation group and control group subjects were to conventional drug treatment including(anti platelet aggregation,improve cerebral circulation,nutrition,and control the basic diseases such as comprehensive drug)and cognitive training(1times a day,every time 30 min,5 times a week,a total of 4 weeks training),the observation group to right DLPFC 0.5 Hz,1 Hz and left DLPFC 5 Hz,10 Hz rTMS treatment;before treatment and 4 weeks after treatment,MoCA scale score,MMSE scale score,P300 amplitude and latency changes in patients with mild cognitive impairm-ent after cerebral infarction were compared,and RMT(resting motion threshold)changes after 0.5Hz,1Hz,5Hz and 10 HzrTMS were observed.chi-square test is adopted for counting data;The measurement data in line with the normal distribution were represented by mean standard deviation,the measureme-nt data in non-normal distribution were represented by quartile spacing,the comparison of multiple groups of non-normal distribution data was conducted by kruskal-willis H test,and the comparison of two groups of non-normal distribution data was conducted by wilcoxon rank sum test.Spearman rank correlation analysis was used for correlation analysis.Bilateral significance level was 0.05。Results:(1)there were no significant differences in MoCA scale score,MMSE score,P300 latency,amplitude and RMT between the observation group and the control group before treatment(P > 0.05).(2)4 weeks after treatment,the observation group and control group in MoCA score,MMSE score increases,the P300 latency period shorten,amplitude increases,RMT is reduced,statistically significant difference(P < 0.05),and the rTMS is more significant difference between groups(P < 0.05),and further 0.5 Hz,the 1 Hz group,5 Hz,10 Hz group comparison between each group,found no significant difference(P > 0.05).Conclusion:(1)rTMS of 0.5hz group,1Hz group,5Hz group and 10 Hz group can effectively improve the cognitive function of patients with mild cognitive impairment after cerebral infarction(2)High and low frequency rTMS combined with cognitive function training has similar efficacy,both of which can effectively improve the cognitive function of patients with mild cognitive impairment after cerebral infarction,and the RMT value also decreases as the cognitive function of patients improves.