Clinical Study On The Treatment Of Hepatic And Renal Insufficiency Of Ankylosing Spondylitis With Bushen Qiangji Decoction

ObjectiveIn this study,a simple,randomized and controlled method was used to investigate the efficacy of Bushen Qiangji Decoction in the treatment of ankylosing spondylitis patients with hepatorenal insufficiency by statistic the changes of symptoms and related treatment indicators before and after treatment,so as to evaluate the efficacy and safety of the prescription,and to provide a basis for the clinical application of traditional Chinese medicine in the treatment of ankylosing spondylitis.Methods66cases of ankylosing spondylitis in outpatient and inpatient departments were randomly divided into two groups,33cases in each group.The observation group was treated with Bushen Qiangji Decoction,while the control group was treated with celecoxib as basic treatment.Follow-up,clinical evaluation,safety evaluation and records were conducted at 0,12 weeks of treatment.ResultsThere were significant differences between the treatment group and the control group in improving patients’ condition and quality of life(lowering the scores of patients’ BASDAI,BASFI,pain VAS and overall VAS),improving symptoms of traditional Chinese medicine,improving spinal mobility,reducing erythrocyte sedimentation and C-reactive protein(P<0.05),and the treatment group was significantly better than the control group.The treatment group was better than the control group in terms of inflammation indexes(P<0.05).The difference was significant(P<0.05).ASAS20 evaluation showed that 27 patients in the treatment group met the standard and 19 in the control group met the standard,which indicated that the treatment scheme in the treatment group was better than that in the control group.The evaluation of TCM symptom integral showed that the total effective rate of the treatment group was 87.10%and that of the control group was 80.65%.Compared with the control group,the treatment group had better clinical effect.ConclusionBushen Qiangji Decoction is effective in treating AS of liver and kidney insufficiency syndrome.It can improve patients’ quality of life,spinal activity and reduce inflammatory indicators.