Multivariate Analysis Of The Effectiveness Of Affecting Infantile Spasms

Objective:To summarize and compare the short-term effects of adrenocorticotropic hormone(ACTH)and methylprednisolone in the treatment of infantile spasms(IS),and to explore the relevant factors affecting the effectiveness of treatment.Methods:This research adopts a retrospective method to study the clinical efficacy of 51children with IS treated with intravenous infusion of adrenocorticotropic hormone(ACTH)or methylprednisolone in the Children’s Hospital of Shanxi Province from 2014 to 2018.Results:1.There was no significant difference in the efficiency of ACTH treatment compared with the effective rate of methylprednisolone treatment.(P>0.05).2.There was no significant difference in the effective rate of normal or abnormal development before the onset of the disease(P>0.05).3.There was no statistically significant difference in the effective rate of normal or abnormal brain imaging.(P>0.05).4.There was a statistically significant difference between the course of treatment in the course of less than or equal to 3 months and the effective rate of treatment in the course of more than 3 months.(χ~2=7.318,P=0.007<0.05).5.Logistic regression analysis was performed to screen out course of disease as an independent risk factor affecting treatment effectiveness(OR=0.205,Sig=0.023).Conclusions:ACTH and methylprednisolone are effective in the treatment of most children with IS.Normal or abnormal development before the onset of the disease and brain imaging have no effect on treatment effectiveness.The course of disease is an independent risk factor affecting the effectiveness of treatment.