Preventive Effect Of Trimetazidine Hydrochloride Combined With Atorvastatin On Contrast-induced Nephropathy After Percutaneous Coronary Intervention

Purpose: We performed this study to evaluate the efficacy of TMZ combined with atorvastatin in preventing contrast induced nepropathy in patients with unstable angina undergoing Percutaneous Coronary Intervention.Methods: From November 2018 to February 2019,99 consecutive patients suffer from unstable angina received percutaneous coronary intervention were selected and randomly divided into experimental group(n=49)and control group(n=49).The experimental group received trimetazidine hydrochloride(20mg 3/d)and atorvastatin 20 mg 1/night 2 days before and after operation.The control group received atorvastatin 20 mg 1/night.Both of the two groups received hydration therapy.The changes of creatinine and cystine C were observed before and 48 hours after PCI.The incidence of contrast induced nephropathy was observed.Contrast induced nephropathy was defined as acute renal injury within 72 hours after exposure to contrast medium,the absolute value of serum creatinine increased by 44.2 μ mol / L(0.5mg/dl)or increased by more than 25% compared with the basic value.Other factors such as renal vascular thrombosis and chronic renal insufficiency should be excluded.Results: There were no statistically significant differences in general conditions,treatment and basic diseases between the two groups.The overall incidence of contrast induced nephropathy was 4%,4 patients(8%)in the control group developed contrast induced nephropathy,and no such things occurred in the experimental group,the difference was statistically significant.The increase of creatinine,cystatin C in the experimental group 48 hours after the surgery was not significant,and the difference was not statistically significant(P>0.05).Creatinine and cystatin C in the control group increased at 48 hours after surgery,and the difference was statistically significant(P<0.05).There was no significant difference in creatinine and cystatin C values between the experimental group and the control group before Percutaneous Coronary Intervention.Creatinine and cystatin C in the control group were significantly higher than those in the experimental group 48 hours after operation,with statistically significant differences(P<0.05).Conclusion: Trimetazidine has been described as a cellular anti-ischemic agent,combinen atorvastatin can reduce the incidence of contrast-induced nephropathy and contribute to the prevention of contrast-induced nephropathy.