Comparison Of Different Pharmacokinetic Models In DCE-MRI For Predicting HIFU Ablation Of Uterine Fibroids

Objective:To investigate the effect of different pharmacokinetic models in the prediction of high intensity focused ultrasound(HIFU)on the ablation rate of uterine fibroids in dynamic quantitative magnetic resonance imaging(DCE-MRI)quantitative analysis.Methods: Fifty-six patients with uterine fibroids admitted to the First Affiliated Hospital of Chongqing Medical University from August 2015 to August 2017 were enrolled in this study.All these patients underwent DCE-MRI before HIFU,and were divided into high ablation rate group and low ablation rate group according to the postoperative ablation rate after the ETL and RR models were used to calculate the quantitative parameters.The correlation among each parameter value and ablation rate,the differences among the parameters of each group were analyzed and evaluated by the receiver operating characteristic curve.Results: Ktrans、Kep、Ve、Vp of the ETL and RR Ktrans,RR Kep,RR Vp of the RR model were negatively correlated with ablation rate(R2=0.116-0.285,P<0.05).The values of Ktrans and RR Ktrans,Kep andRR Kep,Ve、 RR Vp in the low ablation rate group were all lower than those in the high ablation rate group with statistically significant difference(P<0.05).There was no statistically significant difference in the values of Vp between the above two groups(P>0.05).The best predicted values of Ktrans,Kep,Ve and RR Ktrans,RR Kep,RR Vp were 1.0349,1.0625,0.7000 and 2.9380,1.0619,0.6606,and the area under the corresponding ROC curve were 0.781,0.725,0.722 and 0.728,0.824,0.790,respectively.Conclusion:Both of the quantitative analysis of the ETL model and RR model can effectively predict the ablation rate of HIFU in the treatment of uterine fibroids.RR Kep of the RR model has the best prediction performance.