| Background: pancreatitis-associated ascitic fluid(PAAF)contributes to the elevation of intra-abdominal pressure(IAP)and plays an important role in the inflammatory response in patients with moderately severe acute pancreatitis(MSAP)and severe acute pancreatitis(SAP).Therefore,patients with MSAP/SAP should benefit from percutaneous catheter drainage(PCD)of PAAF.The purpose of the study was to evaluate the effects of the PCD in early-stage MSAP/SAP.Methods: The PCD group comprised 84 consecutive patients with MSAP/SAP who underwent PCD of PAAF in early-stage of the disease.The control group comprised 187 consecutive patients with MSAP/SAP who did not undergo the PCD.The two groups were compared in terms of IAP,systemic inflammatory response syndrome(SIRS),organ failures,death,as well as serum levels of high-sensitivity C-reactive protein(hs-CRP)and inflammatory cytokines.Results: The median interval between the onset of MSAP/SAP and the PCD in PCD group was 1(0-6)day,and the median duration was 5(2-8)days with average total drainage volume of 2962 ± 1995 ml.Average IAP of the two groups was comparable at day 0 of admission(16.97 ± 4.73 mm Hg vs 16.31 ± 5.04 mm Hg,P = 0.32),but that of PCD group was lower than control group at day 3(12.82 ± 4.06 vs 14.16 ± 4.27,P = 0.02).SIRS presented in 100%(84/84)and 98.9%(185/187)patients in PCD group and control group respectively at day 0,and SIRS was resolved in 76.2%(64/84)and 64.3%(119/185)patients in PCD group and control group respectively at day 7.The new onset organ failures in PCD group were significantly less than that in control group(15.48% vs 31.01%,P = 0.02).The mortality rate in PCD group was 4.76%(4/84),while that in control group was 6.95%(13/187).The difference between the two groups was not significant(P = 0.49).Conclusions: PCD of PAAF in early-stage decreased IAP and modulated the inflammatory response in patients with MSAP/SAP.Patients with MSAP/SAP benefit from the PCD on clinical outcomes. |
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