Clinical Analysis Of 111 Cases Of Malignant Ovarian Germ Cell Tumor

Objective:By analyzing the clinical and pathological characteristics of Malignant Ovarian Ovarian cancer(MOGCT),the article discussed the inference of factors(age,histopathological types,surgical pathological stage,surgical methods,chemotherapy and other)on prognosis,gestation and fertility.Methods: 111 MOGCT cases which happened between 2002.1.1 and 2018.12.31 were collected in Qingdao university affiliated hospital.In the case study,the patient fertility rate was analyzed by Fisher’s exact probability.The clinical data was analyzed by SPSS 22.0 and it has a significant effect on patient fertility rate if P<0.05.Results:1 The average age of 111 MOGCT cases was 23.Younger patients are more likely to be attacked.There were 58 patients with abdominal distension and abdominal pain,20 patients with self-palpation of abdominal mass or conscious enlargement of abdominal circumference.Among 46 patients with elevated serum AFP,23 were yolk sac tumors,6were mixed germ cell tumors containing yolk sac tumors,2 were primary choriocarcinoma with elevated serum HCG,and NSE and LDH were highly expressed in asexual cell tumors and immature teratomas.2 The histologic type has no statistics significance by the analysis of survival rate in 2years and 5 years(P>0.05);Surgical pathologic stage(I-II and III-IV)have no statistically significance by the analysis of survival rate in 2 years(P > 0.05).However,there were statistics significance in surgical pathologic stage by the analysis of survival rate in 5 years(P<0.05).3 Whether preserve the fertility or not was no significant difference in the two years and five years survival rates(P>0.05).There was no significant difference in the two years and five years survival rates on whether comprehensive staging laparotomy or not(P>0.05).The two years and five years survival rates were analyzed it showed that whether chemotherapy or not had statistics significance(P<0.05).4 Of the 26 cases,the pregnancy rate was 96.1%.The rate of successful delivery was72%.And the histopathological types,surgical pathology,modus operandi and chemotherapy had no statistics significance to fertility rate(P>0.05).Conclusion:1.The younger women are greater likely attacked by MOGCT.The main clinical features are abdominal pain,abdominal distension,pelvic mass and the rises of specific serum tumor markers(such as: AFP and HCG).In addition,the increase of serum NSE and LDH was also helpful for disease diagnosis and condition monitoring.2.The prognosis of patients with early FIGO stage was significantly better than the patients with advanced stage.Although there was no significant difference in the survival rate of patients with different histopathological types,the prognosis of patients with asexual cell tumor was better than the patients with yolk sac tumor.3.Conservative surgery is better for young patients.It will significantly improve the prognosis with standard,adequate and combined chemotherapy.4.Histopathological types,surgical pathological stages,surgical methods and chemotherapy had no significant effect on pregnancy and fertility of patients with fertility requirements.