The Clinical Analysis Of Cerebral Vein And Sinus Thrombosis: A Review Of 68 Cases

Aim To analyze the clinical features,diagnosis and treatment of patients with cerebral vein and sinus thrombosis(CVST)in different gender,especially the clinical features of the maternal.Object We observed 68 cases of clinical diagnosed CVST patients.Methods All patients are divided into two groups by different gender.The study retrospectively analyzes the age,etiology,clinical manifestations,imaging findings,laboratory examination,treatment and prognosis.We also divided the female patients into the maternal and the non-maternal,analyzing the difference of clinical features.Results The onset age of most patients focus on 20 to 59 years old.The common causes of CVST are infection,the stage of pregnancy or puerperium,oral contraceptives,tumor,dural arteriovenous fistula(DAVF)and so on.The patients with unknown etiology have statistics difference in different gender(P=0.028).Headache is the commonest first symptom of patients(87.5%).Except for nausea and vomiting(P=0.007),clinical features have no significant gender difference.There is significant difference between the maternal and the non-maternal patients in the clinical manifestations including seizure,focal neurological deficits symptoms,coma,drowsiness,cerebral haemorrhage and subarachnoid haemorrhage(All P <0.05).There are 81.6% cases with brain CT abnormal,including hyperdensity of sinus and brain parenchyma damage.There are 84.6%,63.6%,69.2% cases with increased cerebrospinal fluid pressure,high-sensitivity C-reactive protein and D-dimer.8/12 patients have the tendency of thrombophilia.There are 5 patients with DAVF who did not benefit from the anticoagulant therapy.Most patients have good prognosis,and there is no difference in gender.The total mortality is 8.8%.Conclusion The incidence of CVST focus on the young people,the common causes of CVST are infection、the stage of pregnancy or puerperium,oral contraceptives.The maternal patients suffer more severe brain parenchymal lesions.Brain CT can be an important imaging examination to screen CVST.The patients with DAVF have poor anticoagulant effect.Most patients have good prognosis.