Effect Of Peripheral Blood Lymphocyte/Monocyte And Lactate Dehydrogenase Ratio On Prognosis Of Diffuse Large B Cell Lymphoma

Objective:The effect of the ratio of lymphocyte to monocyte ratio(LMR),LMR and lactate dehydrogenase(LDH)on the prognosis of patients with diffuse large B-cell lymphoma was studied.Methods:Retrospective analysis of clinical data of 107 newly diagnosed patients with DLBCL,including age,gender,stage,B symptoms,IPI score,ECOG score,absolute lymphocyte count,absolute value of monocytes,lymphocyte to monocyte ratio(LMR)SUVmax of lactate dehydrogenase(LDH),LMR/LDH,and PET-CT.The ROC curve determines the limits of LMR and LMR/LDH;the chi-square test is used to analyze the correlation of clinical factors of LMR,LMR/LDH and DLBCL;Spearman correlation analysis determines the correlation between serum LDH level and SUVmax of PET-CT;The Kaplan-Meier protocol compared the overall survival(OS)and progression-free survival(PFS)of the LMR and R groups in different groups;the Cox proportional hazards model was used to analyze the multivariate analysis of prognostic factors.P <0.05 was considered statistically significant,and P < 0.01 was considered to be statistically significant.Results:1.The optimal limit values for LMR and LMR/LDH(%)were determined by ROCcurve,which were 2.535,0.35% respectively,and were statistically significant.2.LMR < 2.535 is more likely to occur in patients with late clinical stage,B symptoms,higher IPI score,higher ECOG score,and greater LDH than normal.LMR/LDH has the same trend as LMR.3.Spearman correlation analysis showed a significant correlation between serum LDH and SUVmax in PET-CT scans,indicating indirectly that LDH may reflect tumor burden in patients with DLBCL.4.K-M survival analysis showed that the PFS rate and OS rate of the high LMR group were significantly better than the low LMR group,and the difference was statistically significant(P<0.05).5.K-M analysis showed that the PFS rate and OS rate of the high LMR/LDH group were significantly better than the low LMR/LDH group,and the difference was statistically significant(P<0.05).6.Multivariate COX analysis LMR/LDH was more potent than single LMR prediction and was an independent prognostic factor for patients with DLBCL.Conclusion:LMR and LMR/LDH are simple and feasible indicators for predicting the prognosis of patients with DLBCL.LMR/LDH has a higher predictive value for DLBCL and is an important prognostic indicator for DLBCL.