Expression Of Serum Sphingosine-1-phosphate And Its Clinical Significance In Patients With Acute Cerebral Infarction

Objective:To investigate the changes of serum S1 P concentration in patients with acute cerebral infarction at early stage and its relationship with the degree of nerve defects and intracranial vascular lesions in patients with acute cerebral infarction;To evaluate the changes of serum S1 P concentration in patients with cerebral infarction complicated with hypertension and diabetes,in order to provide specific indicators for predicting the condition and prognosis of patients with cerebral infarction.Methods:52 patients with acute cerebral infarction within 72 hours after diagnosis were collected as the case group.The healthy control group included 18 healthy subjects.The expression levels of S1 P in serum of the two groups were detected.The case group was divided into different sub-groups and the serum S1 P level in different sub-groups were detected.Results:1.In terms of demographic factors,there was no significant difference in age between the case group and the control group(P>0.05),and the gender difference was statistically significant(P<0.05).Related parameters of blood lipids TG there was no statistically significant difference(P>0.05),LDL、HDL、TC was statistically significant difference between the two groups(P<0.05);The expression of S1 P in serum is higer in cerebral infarction group than in healthy control group(P<0.05);2.Serum S1 P level was not correlated with gender,age,hypertension,LDL,HDL,TC,TG(P>0.05),but was correlated with diabetes(P< 0.05).However,the correlation was very weak(r<0.3);3.There was no significant difference in serum S1 P expression between groups with NIHSS score<6 and group with NIHSS score≥6(P>0.05);4.The expression level of serum S1 P in patients with large vascular cerebral infarction was higher than that in patients with small vascular cerebral infarction,the difference was statistically significant(P<0.05);5.There was no significant difference in serum S1 P expression between the cerebral infarction group with hypertension and the infarction group without hypertension(P>0.05).Serum S1 P concentration of patients with cerebral infarction with diabetes was higher than that of patients without diabetes,and the difference was statistically significant(P<0.05).Serum S1 P concentration of cerebral infarction patients with hypertension and diabetes was higher than that of cerebral infarction patients with diabetes,and the difference wasn’t statistically significant(P>0.05).Conclusion:1.The increase of serum S1 P level in the acute phase of cerebral infarction may provide a basis for the early diagnosis of cerebral infarction.2.The expression of serum S1 P is different in small or large types of cerebral infarction,suggesting that S1 P can be used as one of the basis for etiological classification and guiding clinical treatment.3.The serum S1 P level of cerebral infarction patients with diabetes was higher than that of patients without diabetes,Which indicates that hyperglycemia may aggravate brain injury and the importance of early control of risk factors in patients with cerebral infarction...