Study On The Relationship Between Expression Of PD-L1 And The Efficacy Of Neoadjuvant Therapy For Rectal Cancer

Objective: The expression of PD-L1 before neoadjuvant therapy for rectal cancer,and to explore the correlation between its expression and neoadjuvant therapy and clinical and pathological features of rectal cancer.Methods:1.A retrospective selection of patients from the second surgical department of the Fourth Hospital of Hebei Medical University from November 2015 to November 2018 was diagnosed as rectal cancer by biopsy.The clinical evaluation was local metaphase and advanced rectal cancer.After neoadjuvant therapy Forty-three patients underwent TME surgery for 6-8 weeks.2.Tumor tissue wax blocks were collected from the pathology department before neoadjuvant treatment,tissue microarrays were prepared,and immunohistochemical detection of PD-L1 molecules was performed.3.Data analysis was performed using SPSS21,and the statistical method was tested according to the use criteria,Pearson chi-square test,chi-square test for continuity correction,and Fisher’s test.Logistic regression was used for the analysis of multiple factors,with P<0.05 being statistically significant.Results: Among the 43 patients enrolled,5 cases(11.6%)were positive for PD-L1 expression.Among them,the clinical data showed that the gender,age,distance from the anus,clinical evaluation of lymph node invasion,clinical T stage cT3/cT4 and PD-L1 expression were not statistically different.There was no significant difference in the expression of PD-L1 between the invasive or non-invasive pathological data,the presence or absence of vascular tumor,the grade of tumor regression,the pathological T stage and the neoadjuvant treatment.There was a statistical difference in the presence or absence of lymph node metastasis and PD-L1 expression in the pathological data(P=0.039<0.05).Conclusions:1.There was no significant correlation between the expression of PD-L1 and neoadjuvant therapy before neoadjuvant therapy with neoadjuvant therapy with long-term radiotherapy and two Xelox regimens.2.In the cases of local matephase and advanced rectal cancer,the expression of PD-L1 before neoadjuvant therapy was positively correlated with the presence or absence of lymph node metastasis.