Clinical Observation Of Xuebijing In Regulating Inflammatory Response Index And Insulin Dosage In Patients With Sepsis

Objective:Through the observation of various clinical trials,the clinical effect of xuebijing injection,a Chinese patent medicine,on sepsis(internal obstruction of stasis toxin)and the effect on the basic dosage of c-reactive protein,procalcitonin and glargine insulin were discussed,and the treatment of sepsis was guided from a new perspective.Methods:The patients who were hospitalized in ICU of the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine from August 2017 to February 2019 and met the inclusion criteria were studied.According to the blind method,randomized and placebo parallel control method,the patients were divided into experimental group and control group(32 persons each).According to the 2016 International Guidelines for the Treatment of Severe Sepsis/Septic Shock,both groups were given routine comprehensive treatment.The experimental group was treated with 100 ml Xuebijing injection and diluted with 0.9%Nacl 100 ml in conventional comprehensive treatment,while the control group was treated with0.9%Nacl 200 ml in conventional comprehensive treatment.Blood cell analysis,CRP,PCT,GLU,PLT,PT,APTT,FIB,DDIMER,ALT,AST,STB,Cr,BUN,blood gas,electrocardiogram and urinary routine were detected before treatment and on the 4th and 7th days after treatment.Changes of serum CRP,PCT levels,insulin glargine basic dosage,SOFA score,APACHE II score and residence time in ICU were recorded and analyzed.The score of TCM syndromes and the score of TCM efficacy.Results:1.The general data comparison before treatment:two groups of objects of age,gender,SOFA and APACHEⅡscore statistics such as no significant difference(P>0.05).2.Comparison between the two groups after treatment:SOFAscore,APACHEII score,C-reactive protein,procalcitonin,insulin glargine basic dosage and TCM syndrome score of the two groups were all decreased on the 4th and 7th day after treatment,and the decline of the experimental group was better than that of the control group,with statistical significance(P<0.05).The ICU time of the experimental group was less than that of the control group,and the difference was statistically significant(P<0.05).3.Intra-group comparison after treatment: the results of all the observation indexes in the two groups on the 7th day after treatment were significantly lower than those on the 4th day after treatment,with statistically significant differences(P<0.05).4.Comparison of safety indexes:ALT,AST,BUN and Cr values of patients in the two groups were improved after medication compared with those before medication,and the experimental group was superior to the control group and within the safe range,with statistically significant differences(P<0.05).Conclusion:1.Xuebijing injection can regulate the level of inflammatory reaction indicators and basic insulin dosage in Sepsis patients with internal obstruction of stasis toxin,so as to improve the clinical efficacy.2.Xuebijing injection can reduce the levels of c-reactive protein and procalcitonin in the serum of Sepsis patients with internal obstruction of stasis toxin.3.Xuebijing injection can reduce the basic dose of insulin glargine in Sepsis patients with internal obstruction of stasis toxin.4.Blood will net injection can improve Sepsis(blood stasis poison resistance)in patients with SOFA score,APACHEⅡscore and TCM syndrome score.5.Xuebijing injection can shorten the hospitalization time of Sepsis patients.6.Xuebijing injection could improve the Sepsis,ALT,AST,BUN and Cr values in the serum of patients with internal obstruction of stasis toxin.