Pharmacodynamics Interaction Between Dexmedetomidine And Sufentanil During Anesthetic Induction:A Response Surface Model Analysis

Background Dexmedetomidine combined with opioids has been extensively used to blunt cardiovascular responses to endotracheal intubation.To determine the dose-response relationship when they are co-administered,we characterized their interaction by using response surface methods.Methods According to a simulation of the slices design,a total of 120 patients for scheduled elective gynecological operations received different dose pairs of dexmedetomidine(0 ~ 1.1 ?g/kg)and sufentanil(0.1 ~ 0.5 ?g/kg),as well as propofol and rocuronium for anesthesia induction.After reaching the peak effect for each dose pair of drugs,the circulatory response to intubation is recorded.The pharmacodynamic interactions between dexmedetomidine and sufentanil are investigated by the Logit interaction model.Result The response surface model revealed the interaction between dexmedetomidine and sufentanil was additive.Besides,The doses that produce 50% of the maximal effect for sufentanil and dexmedetomidine to laryngoscopy and intubation was 0.37 ?g/kg and 1.64 ?g/kg,respectively.Conclusion Dexmedetomidine alone is not an effective drug for ablating the noxious response to intubation in clinically relevant concentrations,but it could effectively reduces the dose of sufentail in a additive manner.