Association Of Innate Immune Gene Copy Number Varation With Non-small Cell Lung Cancer Progression And Prognosis

Lung cancer is one of the major public health problems.It is one of the most serious malignant tumors to human health.At present,the diagnosis and treatment level of lung cancer has improved year by year,but its prognosis is still not optimistic,and its pathogenesis is still unclear.Therefore,the identification of biomarkers related to lung cancer at the molecular level is of great significance for the understanding of lung cancer pathogenesis and prognosis evaluation.Analysis gene expression profile data of nonsmall cell lung cancer and adjacent tissues in TCGA database by DEseq and edgeR and screening differentially expressed genes for GO and KEGG pathway analysis.GEPIA and Cox proportional hazards regression models were used to analyze the relationship between differentially expressed innate immune genes and progression and prognosis of non-small cell lung cancer.CNV,RNA Seq V2,and clinical data were used to analyze the correlation of innate immune gene copy number variation with mRNA expression levels and prognosis of non-small cell lung cancer.It was found that differential expression of innate immune genes F10,WASF1,A2 M,C7 and C7,C8 B,CLDN18 affects lung adenocarcinoma and progression of lung squamous cell carcinoma.WASF1 affects the prognosis of patients with lung adenocarcinoma,and C7 affects the prognosis of patients with lung squamous cell carcinoma.IFNE gene copy number variation is associated with gene expression and affects lung adenocarcinoma prognosis.This study is helpful to understand the role of innate immune genes in the occurrence and prognosis of non-small cell lung cancer,and provide a theoretical basis for the selection of therapeutic targets for non-small cell lung cancer.Figure 18;Table12;Reference 58...