The Impact Of Atosiban On Pregnancy Outcomes In Infertile Women With Different Times Of Transfer Failure Undergoing Frozen-thawed Embryo Transfer

Objective 1.To investigate the impact of atosiban administered before frozen-thawed embryo embryo transfer on pregnancy outcomes in infertile patients.2.To observe the clinical effect of atosiban on infertile patients with different times of embryo transfer failure.Methods This study is a retrospective study.According to the inclusion and exclusion criteria,the data of infertile patients undergoing frozen-thawed embryo transfer in the Reproductive Medical Center of Tianjin Obstetric and Gynecologic Hospital from January 2017 to December 2017 were screened.A total of 631 cycles of frozen-thawed embryo transfer were finally non-randomly divided into three groups according to the times of embryo transfer failure,which were:zero time(n = 268),one time(n = 158),two or more times(n = 205).Each group then was divided into treatment group who received intravenous administration of atosiban before FET with a total dose of 37.5 mg and control group without special treatment.All patients received D3 cleavage stage embryos and at least one was of high quality.Conventional luteal support was given after FET.The IR,PPR,CPR,OPR,LBR,multiple pregnancy rate,abortion rate and ectopic pregnancy rate were compared between the treatment group and control group overally and in 3 groups respectively.Results 1.There were no significant differences in IR(41.2% vs 36.9%),PPR(78.0% vs 71.9%),OPR(56.8% vs 52.5%)and so on between the atosiban treatment group and the control group(P > 0.05),but all showed improvements.2.Among the groups of 0,1,and more than 2 embryo transfer failures,there were no significant differences in IR(46.2% vs 45.5%,47.2% vs 44.5%,27.3% vs 22.6%),PPR(85.2% vs 80.2%,74.7% vs 69.6%,68.4% vs 65.6%),LBR(50.6% vs 46.2%,51.9% vs 49.4%,37.9% vs 29.1%)and so on between the atosiban treatment group and the control group(P > 0.05),but all showed improvements.Conclusion1.In this study,atosiban before frozen-thawed embryo transfer could not significantly but tends to improve the pregnancy outcomes of infertile patients.2.In this study,atosiban before frozen-thawed embryo transfer could not significantly but tends to improve the pregnancy outcomes of infertile patients with 0,1 or more than 2 embryo transfer failures.