Effect Of Patient-controlled Intravenous Analgesia With Dexmedetomidine Mixed With Sufentanil On Sleep Quality After Laparoscopic Colorectal Tumor Resection

Objective: To evaluate the effects of patient-controlled intravenous analgesia with dexmedetomidine mixed with sufentanil on sleep quality after laparoscopic colorectal tumor resection.Methods: Forty patients(aged 37-65 years,ASA ⅠorⅡ)scheduled for laparoscopic colorectal tumor resection were randomly divided into the following 2 groups:group S(n=20,sufentanil)and group SD(n=20,sufentanil plus dexmedetomidine).In group S,PCIA solution contained sufentanil 2μg/kg and ramosetron 0.6 mg in 100 ml of normal saline.In group SD,PCIA solution contained sufentanil1.5μg/kg,dexmedetomidine 1.5μg/kg and ramosetron 0.6 mg in 100 ml of normal saline.The PCA pump was set up with a 0.5ml bolus dose,a 15 min lockout interval and background infusion at a rate of 2 ml/h.The anesthetic method was endotracheal intubation and combined intravenous inhalational anesthesia in both groups,and the PCIA pump was given after the surgery immediately to patients for postoperative analgesia.Polysomnography measures were performed the the first night after surgery.And the subjective sleep quality score was also recoreded before and after surgery.Visual analogue scale(VAS)score and Ramsay sedation scores were recorded at 1,2,6 and 12 h after surgery.Results: Compared with group S,N1 stage sleep was decreased,and N2 stage sleep was increased in group SD(P <0.05),sleep efficiency index,and subjective sleep quality were increased in group SD(P <0.05).There was no significant difference in N3 and REM stage sleep between two groups(P>0.05).Patients in group SD had a lower VAS score and a higher Ramsay sedation score at 2,6 h after surgery(P <0.05).Conclusion: PCIA with dexmedetomidine mixed with sufentanil not only can offer effective analgesia,but also can improve the sleep efficiency after laparoscopic colorectal tumor resection in the patients.