Clinical Preliminary Study Of Corneal Endothelial Cell Changes Before And After Trabeculectomy For Primary Angle-closure Glaucoma

Purpose: To observe and compare corneal endothelial cells(CECs)changes in patients with primary angle-closure(PACG)before and after traveculectomyMethods: It was a prospective study on 24 eyes of 24 patients with PACG(including 12 patients with APACG and CPACG respectively).Indirect specular microscopy was performed on central corneas,endothelial images were acquired,and endothelial cell density(CD),hexagonality of the endothelial cells(6A),the average cell areas(AVE)and the coefficient of variation of the cell areas(CV)were analyzed one day before,one week,2weeks,one month and 3 months after trabeculectomy surgery.Paired t-test and repeated measures analysis of variance were used to campare the differences among the different groups.Results: The CD、6A、CV and AVE in APACG group after surgery was significantly different with before(p < 0.05).The CD in CPACG group before surgery was significantly higher than after(p < 0.05),and there was no significant difference between the two groups about 6A、CV and AVE.Three months after surgery,there was a statistically significant difference in the variance of CEC changes between APACG group and CPACG group(p <0.05).Conclusions: Trabeculectomy affects corneal endothelium in the patients with PACG.As for APACG,it is helpful for CEC recovery in 3 months after surgery.While in the patients with CPACG,there is no significant effects at the same time.